Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model
Title:
Induction and Characterization of Pulmonary Hypertension in Mice using the Hypoxia/SU5416 Model
Author:
Bikou, Olympia
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (430 seconds)
Series:
Medicine
General Note:
Title from resource description page
Abstract:
This protocol describes the induction of pulmonary hypertension (PH) in mice based on the exposure to hypoxia and the injection of a VEGF receptor antagonist. The animals develop PH and right ventricular (RV) hypertrophy 3 weeks after the initiation of the protocol. The functional and morphometrical characterization of the model is also presented.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/59252