Cover -- Front Matter -- Preface -- Acknowledgment of Reviewers -- Contents -- Executive Summary -- 1 Introduction -- 2 Sensorimotor Integration -- 3 Bone Physiology -- 4 Muscle Physiology -- 5 Cardiovascular and Pulmonary Systems -- 6 Endocrinology and Nutrition -- 7 Immunology and Microbiology -- 8 Radiation Biology -- 9 Behavior and Performance -- 10 Setting Priorities in Research -- 11 Programmatic and Policy Issues -- Appendixes -- Appendix A A Strategy for Research in Space Biology and Medicine in the New Century -- Appendix B Letter of Request from NASA -- Appendix C Glossary -- Appendix D Acronyms -- Appendix E Biographies of Committee Members.