Part I) Relation between adverse oxidant and inflammatory changes -- 1)Relationship between inflammatory and oxidative pathways in the disease process -- 2) Nitric oxide, the common denominator in oxidative and inflammatory events -- 3) Genomic profiling of the link between oxidative and inflammatory events -- 4) Environmental toxicants inflammation and oxidative stress -- Part II) Role of oxidative events in age-related diseases -- 5) Mitochondrial DNA deletions and oxidative stress -- 6) Oxidative stress and Alzheimer’s disease -- 7) Oxidative stress and Parkinson’s disease -- 8) Oxidative stress, cause or consequence of aging? -- 9) Oxidative events in intracellular signaling -- 10) Oxidative stress and drugs of abuse -- Part III) Role of inflammatory events in age-related diseases -- 11) Limitations of animal models of human inflammatory disease -- 12) Microglial activation in neurodegenerative diseases -- 13) Particle- induced inflammation and cardiovascular disease -- 14) Microglia and inflammation in Parkinson’s disease -- Part IV) Modulation of disease by anti-oxidant and anti-inflammatory agents -- 15) Alzheimer’s disease and anti-oxidant therapy -- 16) Antioxidant, and behavioral therapy in slowing brain aging -- 17) Treatment of age-related disease using micronutrients -- 18)Anti-inflammatory treatment in neurological disease.