Drug Metabolism In Context: Introduction -- Absorption -- Drug Distribution -- Dynamics Of Drug Action -- Drug Clearance -- Dynamics Of Drug Clearance -- Pathways Of Biotransformation – Phase I Reactions: Introduction -- Phase I And Phase Ii Metabolism: General Considerations -- Oxidations Involving The Microsomal Mixed-Function Oxidase System -- Oxidations Involving Other Enzymatic Systems -- Metabolic Reactions Involving Reduction -- Hydrolysis -- Miscellanous Phase I Reactions -- The Fate Of Phase I Reaction Products -- . Pathways Of Biotransformation – Phase I Reactions: Introduction -- Glucuronidation -- Acetylation -- Glutathione Conjugation -- Other Conjugative Reactions -- Concluding Remarks -- Enzymatic Systems Involved In Drug Biotransformation: Ntroduction -- Interaction Between A Drug Substrate And An Enzyme -- Enzyme Systems With Specific Roles -- Final Remarks -- Induction And Inhibition Of Drug-Metabolising Enzymes -- Introduction -- Induction -- Inhibition -- Consequences Of The Above Phenomena -- Dietary And Non-Dietary Factors In Enzyme Induction And Inhibition -- Factors That Influence Drug Biotransformation -- Introduction -- Intrinsic Factors -- Environmental Factors -- Further Observations -- Impact Of Gene Variability On Drug Metabolism -- Introduction -- Basic Principles Of Pharmacogenetics -- Pharmaco-Informatics -- Implications For Third Millennium Medicine -- Drug Interactions And Adverse Reactions: Introduction -- Drug-Drug Interactions -- Interactions Between Drugs And Other Entities -- Adverse Reactions -- Summary -- Strategies For Drug Design -- Introduction -- Pharmacokinetics And Metabolism In Drug Research -- The Role Of Formulation -- Concluding Remarks -- Index.