Title Page -- Copyright -- Table of Contents -- Contributors -- Part 1: Evidence-based neurology: introduction -- Chapter 1: Evidence-based neurology in health education -- Introduction -- Objectives -- Topic selection -- Tutorial -- Post-tutorial -- The critically appraised topic (CAT) -- Resources -- The evidence to support an evidence-based health curriculum -- References -- Chapter 2: Evidence-based medicine in health research -- Introduction -- Using evidence-based principles to develop and answer clinical research questions -- Sound research design with the end result in mind -- Resources for clinical investigators -- Summary -- References -- Chapter 3: Evidence and ethics -- Introduction -- The current ethical framework in health care -- References -- Part 2: Evidence-based neurology in the hospital -- Chapter 4: Thunderclap headache -- Background -- Case scenario -- Framing answerable clinical questions -- Critical review of the evidence -- Conclusions -- Future research needs -- References -- Chapter 5: Coma -- Background -- Monitoring of a comatose patient -- Management -- Clinical examination and scales -- Neuroimaging -- Electrophysiology -- Biomarkers -- Combining various parameters to predict outcome -- Conclusion -- References -- Chapter 6: Acute ischemic stroke and transient ischemic attack -- Background -- Mechanism and pathophysiology -- Epidemiology -- Clinical scenario -- Framing clinical questions and general approach to searching evidence -- Critical review of the evidence -- Epidemiology -- Diagnosis -- Evaluation -- Framing clinical questions and general approach to searching evidence -- Treatment -- References -- Chapter 7: Spinal cord compression -- Introduction -- Spinal cord compression due to tumor - metastatic spinal cord compression -- Clinical questions: management of acute metastatic spinal cord compression.

Spinal cord compression due to infection - spondylodiscitis -- Clinical questions: management of spinal cord compression due to infection -- Spinal cord compression due to degenerative disease - cervical and thoracic spondylotic myelopathy -- Clinical questions: management of spinal cord compression due to degenerative disease -- Spinal cord compression due to trauma - traumatic spinal cord injury -- Clinical questions: management of spinal cord compression due to traumatic injury -- Summary -- References -- Chapter 8: Delirium -- Introduction -- Methodology -- Clinical questions and evidence -- Summary -- Acknowledgments/Disclosures -- References -- Chapter 9: Status epilepticus -- Background -- Framing clinical questions and search for evidence -- Critical review of the evidence for each question -- Summary -- Acknowledgements -- References -- Chapter 10: Raised intracranial pressure -- Introduction -- Methodology -- Summary -- Disclosures -- Acknowledgments -- References -- Chapter 11: Traumatic brain injury -- Critical review of each question -- Control of intracranial hypertension -- References -- Chapter 12: Myasthenia gravis -- Introduction -- Framing of clinical question and search strategy -- Clinical scenario -- Critical review of the evidence for each question -- Clinical scenario -- Critical review of the evidence for each question -- Conclusions -- References -- Chapter 13: Acute visual loss -- Non-arteritic ischemic optic neuropathy -- Arteritic anterior ischemic optic neuropathy or giant cell arteritis -- Retinal vascular occlusion syndromes -- Terson's syndrome -- Stroke -- Optic nerve disorders -- Neuromyelitis optica -- Idiopathic intracranial hypertension -- Non-physiologic vision loss -- References -- Chapter 14: Secondary prevention of stroke -- What can be done to prevent further strokes in stroke survivors?.

Vascular risk factor modification for secondary stroke prevention -- Hypertension -- Dyslipidemia -- Diabetes -- Smoking cessation -- Antithrombotic agents in stroke survivors with atrial fibrillation -- Antiplatelet agents in stroke survivors without atrial fibrillation -- Endarterectomy for symptomatic carotid disease -- Endovascular treatment (angioplasty and stenting) for carotid stenosis -- Obstructive sleep apnea management -- Lifestyle management (eating a balanced diet, limiting salt intake, moderating alcohol consumption, increasing physical activity, and optimizing weight) -- Disclosure -- References -- Part 3: Evidence-based neurology in the clinic -- Chapter 15: Central nervous system infections -- Bacterial meningitis -- CNS tuberculosis -- HSV encephalitis -- Cryptococcal meningitis -- References -- Chapter 16: Evidence-based neuro-oncology -- Introduction -- Best pre-operative medical management -- Best surgical treatment in primary brain tumours -- Best oncological treatment in primary brain tumours -- Best treatment of brain metastasis? -- Summary -- References -- Chapter 17: Epilepsy -- Background -- AED Treatment After First Seizure -- Summary -- AED monotherapy for partial epilepsy -- Addition of second-line AEDs -- Summary -- AED withdrawal for people in remission -- Summary -- Surgery -- Summary -- Summary -- Generalised epilepsy -- Carbamazepine for generalised epilepsy -- Conclusion -- Additional treatments -- Summary -- Abbreviations -- References -- Chapter 18: Cognitive disorders: mild cognitive impairment and Alzheimer's disease -- Introduction -- Framing the clinical questions -- Search strategy -- Clinical questions -- Conclusion -- References -- Chapter 19: Evidence-based treatment of Parkinson's disease -- Background -- Clinical questions -- Search strategy -- Critical review of the evidence -- References.

Chapter 20: Therapies for multiple sclerosis -- Introduction -- Methods -- Clinically isolated syndrome -- Interferon-beta and glatiramer acetate for relapsing-remitting multiple sclerosis -- Natalizumab and fingolimod -- The newest oral therapies: Teriflunomide and dimethyl fumarate -- Secondary progressive MS -- Primary progressive MS -- Dalfampridine -- Conclusions -- References -- Chapter 21: Amyotrophic lateral sclerosis -- Background -- Framing answerable clinical questions -- General approach to the search for evidence -- Critical review of the evidence for each question -- Multidisciplinary care -- Conclusions -- References -- Chapter 22: Peripheral nerve disorders -- Introduction -- Treatment for CIDP -- Treatment for Guillain-Barré syndrome -- Treatment for multifocal motor neuropathy -- Treatment for diabetic polyneuropathy -- References -- Chapter 23: Critical illness neuromyopathy -- Background -- Clinical features and diagnosis -- Framing of clinical question and search strategy -- Clinical scenario -- Critical review of the evidence for each question -- Conclusions -- References -- Chapter 24: Muscle disorders -- Introduction -- Critical review of the evidence for each disorder -- References -- Chapter 25: Sleep disorders -- Background -- Framing clinical questions -- Critical review of evidence -- Conclusion -- References -- Chapter 26: Acute migraine attacks -- Background -- Case scenario -- Framing answerable clinical questions -- Critical review of the evidence -- Conclusion -- Future research needs -- References -- Chapter 27: Therapy of vestibular disorders, nystagmus and cerebellar ataxia -- Introduction -- Principles of the pharmacotherapy of vertigo, dizziness, ocular motor disorders, and nystagmus -- Peripheral vestibular disorders -- Vestibular paroxysmia -- Acknowledgements -- References -- Chapter 28: Neuro-ophthalmology.

Introduction -- Optic neuritis -- Arteritic anterior ischemic optic neuropathy -- Non-arteritic anterior ischemic optic neuropathy -- Acknowledgement -- References -- Chapter 29: Therapeutic connection in neurorehabilitation: theory, evidence and practice -- Background -- Defining therapeutic connection -- Framing clinical questions -- Approach to searching the evidence -- Chapter summary -- Conclusion -- References -- Part 4: Telemedicine feature -- Chapter 30: Evidence-based teleneurology practice -- Introduction to the chapter -- Methodology -- Clinical Questions -- Chapter summary -- Acknowledgements -- Disclosures -- References -- Index -- End User License Agreement.