Emerging Cancer Therapy : Microbial Approaches and Biotechnological Tools.
Title:
Emerging Cancer Therapy : Microbial Approaches and Biotechnological Tools.
Author:
Fialho, Arsenio.
ISBN:
9780470626511
Personal Author:
Edition:
1st ed.
Physical Description:
1 online resource (448 pages)
Series:
Wiley Series in Biotechnology and Bioengineering ; v.2
Wiley Series in Biotechnology and Bioengineering
Contents:
EMERGING CANCER THERAPY -- CONTENTS -- PREFACE -- CONTRIBUTORS -- PART I: LIVE/ATTENUATED BACTERIA AND VIRUSES AS ANTICANCER AGENTS -- 1: SALMONELLA TYPHIMURIUM MUTANTS SELECTED TO GROW ONLY IN TUMORS TO ERADICATE THEM IN NUDE MOUSE MODELS -- 2: THE USE OF LIVING LISTERIA MONOCYTOGENES AS AN ACTIVE IMMUNOTHERAPY FOR THE TREATMENT OF CANCER -- 3: BACILLUS CALMETTE-GUERIN( BCG ) FOR UROTHELIAL CARCINOMA OF THE BLADDER -- 4: LIVE CLOSTRIDIA : A POWERFUL TOOL IN TUMOR BIOTHERAPY -- 5: BIFIDOBACTERIUM AS A DELIVERY SYSTEM OF FUNCTIONAL GENES FOR CANCER GENE THERAPY -- 6: REPLICATION-SELECTIVE VIRUSES FOR THE TREATMENT OF CANCER -- 7: ENGINEERING HERPES SIMPLEX VIRUS FOR CANCER ONCOLYTIC VIROTHERAPY -- PART II: BACTERIAL PRODUCTS AS ANTICANCER AGENTS -- 8: PROMISCUOUS ANTICANCER DRUGS FROM PATHOGENIC BACTERIA: RATIONAL VERSUS INTELLIGENT DRUG DESIGN -- 9: ARGININE DEIMINASE AND CANCER THERAPY -- 10: CYTOSINE DEAMINASE/5-FLUOROCYTOSINE MOLECULAR CANCER CHEMOTHERAPY -- 11: BACTERIAL PROTEINS AGAINST METASTASIS -- 12: PSEUDOMONAS EXOTOXIN A-BASED IMMUNOTOXINS FOR TARGETED CANCER THERAPY -- 13: DENILEUKIN DIFTITOX IN NOVEL CANCER THERAPY -- 14: THE APPLICATION OF CATIONIC ANTIMICROBIAL PEPTIDES IN CANCER TREATMENT: LABORATORY INVESTIGATIONS AND CLINICAL POTENTIAL -- 15: PRODIGININES AND THEIR POTENTIAL UTILITY AS PROAPOPTOTIC ANTICANCER AGENTS -- 16: FARNESYLTRANSFERASE INHIBITORS OF MICROBIAL ORIGINS IN CANCER THERAPY -- 17: THE USE OF RNA AND CpG DNN AS NUCLEIC ACID-BASEDTHERAPEUTICS -- PART III: PATENTS ON BACTERIA/BACTERIAL PRODUCTS AS ANTICANCER AGENTS -- 18: THE ROLE AND IMPORTANCE OF INTELLECTUAL PROPERTY GENERATION AND PROTECTION IN DRUG DEVELOPMENT -- INDEX.
Abstract:
ARSÉNIO FIALHO, PhD, is Associate Professor in the Department of Chemical and Biological Engineering and Principal Investigator for the Institute of Biotechnology and Bioengineering in the Instituto Superior Técnico at the Universidade Técnica de Lisboa, Portugal. His current scientific interests are focused on the study of bacterial proteins, such as azurin and Laz, as novel multi-targeted drug candidates with anticancer activities. He is the author or coauthor of more than fifty papers in peer-reviewed scientific journals and, during the last four years, became the holder of five U.S. patents. Dr. Fialho teaches courses in biochemistry, molecular biology, and bioinformatics. ANANDA CHAKRABARTY, PhD, is Distinguished University Professor in the Department of Microbiology and Immunology at the University of Illinois College of Medicine at Chicago. In addition to more than 250 research publications, he has secured nine U.S. patents during the last four years on azurin and Laz, two bacterial proteins with anticancer, anti-viral and anti-parasitic activities. He also is the recipient of a patent on the first life form, a genetically manipulated pseudomonad designed to degrade multiple hydrocarbons present in crude oil, as decided by the U.S. Supreme Court in 1980 in the celebrated court case Diamond v. Chakrabarty.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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