Toxicity of Alternatives to Chlorofluorocarbons: HFC-134a and HCFC-123 -- Copyright -- Preface -- Contents -- Executive Summary -- ASSESSMENT OF MODEL FOR CARDIAC SENSITIZATION -- EXPOSURE GUIDANCE LEVELS FOR HFC-134A -- EXPOSURE GUIDANCE LEVEL FOR HCFC-123 -- 1 Introduction -- STATEMENT OF TASK -- DEFINITIONS -- Emergency Exposure Guidance Level -- Continuous Exposure Guidance Level -- STRUCTURE OF THE REPORT -- 2 Evaluation of the Dog Cardiac Sensitization Test -- INTRODUCTION -- MECHANISM OF ACTION FOR CHEMICALLY INDUCED ARRHYTHMIAS -- PROTOCOL FOR A CARDIAC SENSITIZATION SCREENING STUDY -- CARDIAC SENSITIZATION EXPERIMENTS INVOLVING SELECTED HALOCARBONS -- CONCLUSION -- REFERENCES -- 3 Exposure Guidance Levels for Hydrofluorocarbon-134a -- INTRODUCTION -- BACKGROUND INFORMATION -- Physical and Chemical Properties -- Occurrence and Use -- TOXICOKINETICS -- TOXICITY INFORMATION -- Acute Toxicity -- Cardiac Sensitization -- Subacute Toxicity -- Subchronic Toxicity -- Developmental Toxicity -- Reproductive Toxicity -- Genotoxicity -- Carcinogenicity -- SUMMARY -- RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVELS -- REFERENCES -- 4 Exposure Guidance Levels for Hydrochlorofluorocarbon-123 -- INTRODUCTION -- RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVELS -- REFERENCES -- Appendix A -- SUPPORTING DOCUMENTATION FOR THE EXPOSURE GUIDANCE LEVELS FOR HYDROCHLOROFLUOROCARBON-123 -- BACKGROUND INFORMATION -- Physical and Chemical Properties -- Occurrence and Use -- TOXICOKINETICS -- TOXICITY INFORMATION -- Effects in Humans -- Effects in Animals -- Single-Exposure Studies -- Repeat-Exposure Studies -- EXPOSURE ASSESSMENT -- RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVEL -- REFERENCES -- ATTACHMENT 1 MATERIAL SAFETY DATA SHEET -- ATTACHMENT 2 HALOTHANE -- BACKGROUND INFORMATION -- Physical and Chemical Properties -- Occurrence and Use -- ACUTE TOXICITY INFORMATION.

Acute Toxicity and CNS Depression -- Cardiac Sensitization -- Effects in Humans -- Malignant Hyperthermia -- Hepatotoxicity -- DISCUSSION -- HCFC-123 AND Halothane Comparison -- Acute Toxicity and CNS Depression -- Cardiac Sensitization -- Malignant Hyperthermia -- Hepatotoxicity -- REFERENCES -- ATTACHMENT 3 SUMMARY OF TOXICITY STUDIES OF HCFC-123 -- I. ANIMAL STUDIES: SINGLE EXPOSURE -- II. ANIMAL STUDIES: REPEAT EXPOSURE -- III. REFERENCES -- ATTACHMENT 4 SUMMARY OF ACUTE PHARMACOKINETIC STUDY OF HCFC-123 IN DOGS BY INHALATION -- OBJECTIVE -- MATERIALS AND METHODS -- Exposure System -- Blood and Tissue Sampling -- Analysis of Blood and Tissue Samples -- RESULTS -- DISCUSSION.