Ubiquitin-Proteasome Proteolytic System : From Classical Biochemistry to Human Diseases.
Title:
Ubiquitin-Proteasome Proteolytic System : From Classical Biochemistry to Human Diseases.
Author:
Ciechanover, Aaron J.
ISBN:
9789812776877
Personal Author:
Physical Description:
1 online resource (242 pages)
Series:
Recent Advances in Human Biology ; v.9
Recent Advances in Human Biology
Contents:
Contents -- Preface -- The Ubiquitin System and Some of Its Roles in Cell Cycle Control -- References -- The Ubiquitin System and the N-End Rule Pathway -- Summary -- The Ubiquitin System -- The N-End Rule Pathway -- Physical Association of Ubiquitin Ligases and the 26S Proteasome -- Peptide Import and the N-End Rule Pathway -- The N-End Rule Pathway and Fidelity of Chromosome Segregation -- Concluding Remarks -- References -- Phosphorylation-Dependent Substrate Recognition in Ubiquitin-Mediated Proteolysis -- Abstract -- Modular Protein Interaction Domains Regulate Dynamic Cellular Behaviour -- Protein-Protein Interactions Determine Specificity in Ubiquitin-Mediated Proteolysis -- Cdk Activity and the Control of DNA Replication -- Discovery of SCF Ubiquitin Ligases -- Phosphorylation-Dependent Substrate Recognition by SCF Complexes -- Conservation of SCF Function in the Cell Cycle -- The Cdc4 Phospho-Degron -- Multi-Site Phosphorylation and Ultrasensitivity -- The Sicl-Cdc4 Interaction: Theoretical Considerations -- Discussion -- Prospects -- References -- The 26S Proteasome: A Supramolecular Assembly Designed for Controlled Proteolysis -- Introduction -- Structural Features of the 26S Proteasome -- Conclusions -- References -- Mechanisms and Regulation of Ubiquitin-Mediated Limited Processing of the NF-kBa Precursor Protein p105 -- Summary -- Introduction -- Discussion -- References -- Regulation of Receptor Tyrosine Kinases by Ubiquitination -- Abstract -- Introduction -- Lessons from Endocytosis of Yeast Membrane Proteins -- Ligand-Induced Ubiquitination and Endocytosis of Receptor Proteins -- Stress-Induced Ubiquitination and Degradation of Receptor Tyrosine Kinases -- Concluding Remarks -- References -- Regulation of p27 Degradation -- Cell Cycle Regulation by Cyclin-Dependent Kinases.
Features and Functions of p27 -- Regulation of p27 Protein Levels by the Ubiquitin-Proteasome Pathway -- Regulation of the G1/S Transition by SCF Complexes -- SCFSkp2 -- Cksl -- Skp2 and Oncogenesis -- Conclusions -- References -- Ubiquitin System-Dependent Regulation of Growth Hormone Receptor Signal Transduction and Effects of Oxidative Stress -- The Cytokine/Hematopoietin Receptor Superfamily -- Signaling Mechanisms of the GHR -- Negative Regulators of GH Signaling -- Ubiquitination of Plasma Membrane Proteins -- The Ubiquitin System and the Stress Response -- References -- Inhibition of the Ubiquitin-Proteasome System by a Viral Repetitive Sequence -- Introduction -- The Art of Hiding -- The GAr is a Transferable Modular Signal -- Repeat Composition and Length -- Mode of Action -- Other Stabilization Signals -- Concluding Remarks -- References -- Autosomal Recessive Juvenile Parkinsonism and the Ubiquitin Pathway -- Abstract -- Introduction -- Parkinson's Disease and AR-JP -- Parkin: The Causative Gene of AR-JP Encoding an E3 Ubiquitin-Ligase -- How Does Loss-of-Function of Parkin Cause AR-JP -- Perspective -- References.
Abstract:
Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory. This book tells the story of the ubiquitin system as we currently know it: from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteasome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes. Sample Chapter(s). Learning Environments Research: Yesterday. Today and Tomorrow (46 KB). Contents: The Ubiquitin System and Some of Its Roles in Cell Cycle Control (A Hershko); The Ubiquitin System and the N-End Rule Pathway (A Varshavsky); Phosphorylation-Dependent Substrate Recognition in Ubiquitin-Mediated Proteolysis (M Tyers et al.); The 26S Proteasome: A Supramolecular Assembly Designed for Controlled Proteolysis (W Baumeister & P Zwickl); Mechanisms and Regulation of Ubiquitin-Mediated, Limited Processing of the NF-κBα Precursor Protein p105 (A Ciechanover et al.); Regulation of Receptor Tyrosine Kinases by Ubiquitination (A Citri & Y Yarden); Regulation of p27 Degradation (J Bloom & M Pagano); Ubiquitin System-Dependent Regulation of Growth Hormone Receptor Signal Transduction and Effects of Oxidative Stress (C M Alves dos Santos & G J Strous); Inhibition of the Ubiquitin-Proteasome System by a Viral Repetitive Sequence (N P Dantuma & M G Masucci); Autosomal Recessive
Juvenile Parkinsonisms and the Ubiquitin Pathway (K Tanaka et al.). Readership: Medical and biomedical students from the undergraduate to the graduate level, academics/lecturers and biomedical companies.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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