Cover -- Title page -- Copyright page -- Dedication -- Note -- Contents -- About the Authors -- Preface -- About the Companion Web Site -- 1: Introduction to Laboratory Animal Medicine -- Animals Used in Research, Product Safety Testing, and Education -- Biomedical Research -- Product Safety Testing -- Education -- Animal Usage Statistics -- Funding Sources -- Regulatory Oversight and Accreditation -- Institutional Animal Care and Use Committee -- Ethical Considerations -- The 3Rs: Replacement, Refinement, and Reduction -- Animal Rights and Animal Welfare -- Random Source versus Purpose Bred Animals -- Nonhuman Primate Use -- Organizations -- American Association for Laboratory Animal Science -- American Society of Laboratory Animal Practitioners -- American College of Laboratory Animal Medicine -- National Association for Biomedical Research -- Foundation for Biomedical Research -- Institute for Laboratory Animal Research -- References -- Further Reading -- 2: Regulations, Policies, and Principles Governing the Care and Use of Laboratory Animals -- Animal Welfare Act and Regulations -- The Chimpanzee Health Improvement, Maintenance, and Protection Act -- Office of Laboratory Animal Welfare and Public Health Service Policy -- Good Laboratory Practice Regulations -- Guide for the Care and Use of Laboratory Animals -- Guide for the Care and Use of Agricultural Animals in Research and Teaching -- Occupational Health and Safety -- Association for Assessment and Accreditation of Laboratory Animal Care International -- Animal Welfare Information Center -- State Regulations -- References -- Further Reading -- 3: Facility Design, Equipment, Housing, and Management -- Laboratory Animal Facility Design -- Biosecurity -- Conventional Facilities -- Barrier Facilities -- Containment or Biohazard Facilities -- Facility Equipment -- Cage Washers.

Watering Equipment -- Food and Bedding Materials -- Housing -- Rodent Housing -- Housing for Other Small Mammals -- Specialized Housing Systems -- Management -- Laboratory Animal Allergies -- References -- Further Reading -- 4: Mice -- Genetics -- Microbiologic Classifications -- Uses -- Behavior -- Anatomic and Physiologic Features -- Breeding and Reproduction -- Husbandry -- Housing and Environment -- Environmental Enrichment and Social Housing -- Feeding and Watering -- Sanitation -- Techniques -- Handling and Restraint -- Identification -- Blood Collection -- Urine Collection -- Drug Administration -- Anesthesia, Surgery, and Postoperative Care -- Imaging Techniques -- Euthanasia -- Humane Endpoints -- Special Techniques: Transgenic Production Technology -- Pronuclear Injection -- Gene Targeting -- Genotyping -- Therapeutic Agents -- Introduction to Diseases of Mice -- Bacterial Diseases -- Viral Diseases -- Parasitic Diseases -- Neoplasms -- Miscellaneous Conditions -- References -- Further Reading -- 5: Rats -- Genetics -- Microbiologic Classifications -- Uses -- Behavior -- Anatomic and Physiologic Features -- Breeding and Reproduction -- Husbandry -- Housing and Environment -- Environmental Enrichment and Social Housing -- Feeding and Watering -- Sanitation -- Techniques -- Handling and Restraint -- Identification -- Blood Collection -- Urine Collection -- Drug Administration -- Anesthesia, Surgery, and Postoperative Care -- Imaging Techniques -- Euthanasia -- Therapeutic Agents -- Introduction to Diseases of Rats -- Bacterial Diseases -- Mycotic Diseases -- Viral Diseases -- Parasitic Diseases -- Neoplasia -- Miscellaneous Conditions -- References -- Further Reading -- 6: Gerbils -- Uses -- Behavior -- Anatomic and Physiologic Features -- Breeding and Reproduction -- Husbandry -- Housing and Environment -- Sanitation.

Environmental Enrichment and Social Housing -- Feeding and Watering -- Techniques -- Handling and Restraint -- Identification -- Blood Collection -- Urine Collection -- Drug Administration -- Anesthesia, Surgery, and Postoperative Care -- Imaging Techniques -- Euthanasia -- Therapeutic Agents -- Introduction to Diseases of Gerbils -- Bacterial Diseases -- Viral Diseases -- Parasitic Diseases -- Neoplasia -- Miscellaneous Conditions -- References -- Further Reading -- 7: Hamsters -- Uses -- Behavior -- Anatomic and Physiologic Features -- Breeding and Reproduction -- Husbandry -- Housing and Environment -- Sanitation -- Environmental Enrichment and Social Housing -- Feeding and Watering -- Techniques -- Handling and Restraint -- Identification -- Blood Collection -- Urine Collection -- Drug Administration -- Anesthesia, Surgery, and Postoperative Care -- Imaging Techniques -- Euthanasia -- Therapeutic Agents -- Introduction to Diseases of Hamsters -- Bacterial Diseases -- Viral Diseases -- Parasitic Diseases -- Neoplasia -- Miscellaneous Conditions -- References -- Further Reading -- 8: Guinea Pigs -- Uses -- Behavior -- Anatomic and Physiologic Features -- Breeding and Reproduction -- Husbandry -- Housing and Environment -- Sanitation -- Environmental Enrichment and Social Housing -- Feeding and Watering -- Techniques -- Handling and Restraint -- Identification -- Blood Collection -- Urine Collection -- Drug Administration -- Anesthesia, Surgery, and Postoperative Care -- Imaging Techniques -- Euthanasia -- Therapeutic Agents -- Introduction to Diseases of Guinea Pigs -- Bacterial Diseases -- Mycotic Diseases -- Viral Diseases -- Parasitic Diseases -- Neoplasia -- Miscellaneous Conditions -- References -- Further Reading -- 9: Chinchillas -- Uses -- Behavior -- Anatomic and Physiologic Features -- Breeding and Reproduction -- Husbandry.

Housing and Environment -- Sanitation -- Environmental Enrichment and Social Housing -- Feeding and Watering -- Techniques -- Handling and Restraint -- Identification -- Blood Collection -- Urine Collection -- Drug Administration -- Anesthesia, Surgery, and Postoperative Care -- Imaging Techniques -- Euthanasia -- Therapeutic Agents -- Introduction to Diseases of Chinchillas -- Bacterial Diseases -- Mycotic Diseases -- Viral Diseases -- Parasitic Diseases -- Neoplasia -- Miscellaneous Conditions -- References -- Further Reading -- 10: Rabbits -- Breeds -- Uses -- Behavior -- Anatomic and Physiologic Features -- Breeding and Reproduction -- Husbandry -- Housing and Environment -- Environmental Enrichment and Social Housing -- Feeding and Watering -- Sanitation -- Techniques -- Handling and Restraint -- Identification -- Blood Collection -- Urine Collection -- Drug Administration -- Anesthesia, Surgery, and Postoperative Care -- Imaging Techniques -- Euthanasia -- Therapeutic Agents -- Introduction to Diseases of Rabbits -- Bacterial Diseases -- Spirochete Infections: Venereal Spirochetosis -- Viral Diseases -- Mycotic Infections -- Parasitic Diseases -- Neoplasia -- Miscellaneous Conditions -- References -- Further Reading -- 11: Ferrets -- Uses -- Behavior -- Anatomic and Physiologic Features -- Breeding and Reproduction -- Husbandry -- Housing and Environment -- Environmental Enrichment and Social Housing -- Feeding and Watering -- Sanitation -- Techniques -- Handling and Restraint -- Identification -- Blood Collection -- Urine Collection -- Nail Trimming -- Drug Administration -- Immunization -- Anesthesia, Surgery, and Postoperative Care -- Imaging Techniques -- Euthanasia -- Therapeutic Agents -- Introduction to Diseases of Ferrets -- Bacterial Diseases -- Mycotic Diseases -- Viral Diseases -- Parasitic Diseases -- Neoplasia.

Miscellaneous Conditions -- References -- Further Reading -- 12: Primates -- Taxonomy -- Strepsirrhini (Lemurs, Lorises, and Galagos) -- Haplorrhini (Tarsiers, Monkeys, and Apes) -- Uses -- National Primate Research Centers -- Behavior -- Anatomic and Physiologic Features -- Breeding and Reproduction -- Husbandry -- Housing and Environment -- Environmental Enrichment and Social Housing -- Feeding and Watering -- Sanitation -- Techniques -- Handling and Restraint -- Identification -- Blood Collection -- Urine Collection -- Drug Administration -- Anesthesia, Surgery, and Postoperative Care -- Euthanasia -- Therapeutic Agents -- Introduction to Diseases of Nonhuman Primates -- Zoonotic Diseases -- Bacterial Diseases -- Mycotic Diseases -- Viral Diseases -- Parasitic Diseases -- Miscellaneous Conditions -- References -- Further Reading -- 13: Research Variables and Quality Control -- Research Variables: Intrinsic and Extrinsic Factors -- Intrinsic Factors -- Extrinsic Factors -- Chain of Infection -- Quality Control -- Health Surveillance Methods -- Animals Used to Monitor Health Status of a Colony -- Diagnostic Laboratories -- Reference -- Further Reading -- Appendix 1: Normal Values -- References for Normal Values -- References -- Appendix 2: Comparative Biologic and Reproductive Values by Species -- References -- Appendix 3: Supportive and Critical Care Products for Laboratory Animal Use -- Answers to Review Questions -- Chapter 1 -- Chapter 2 -- Chapter 3 -- Chapter 4 -- Chapter 5 -- Chapter 6 -- Chapter 7 -- Chapter 8 -- Chapter 9 -- Chapter 10 -- Chapter 11 -- Chapter 12 -- Chapter 13 -- Index.