Causality in Medicine -- The Evolution of the Biomedical Paradigm in Oncology: Implications for Cancer Therapy -- Anticancer Drug Discovery and Development -- Beyond VEGF: Targeting Tumor Growth and Angiogenesis via Alternative Mechanisms -- Aurora Kinases and Their Inhibitors: More Than One Target and One Drug -- Signalling Pathways and Adhesion Molecules as Targets for Antiangiogenesis Therapy in Tumors -- Developing T-Cell Therapies for Cancer in an Academic Setting -- Anticancer Cell Therapy with TRAIL-Armed CD34+ Progenitor Cells -- Linking Inflammation Reactions to Cancer: Novel Targets for Therapeutic Strategies -- Clinical Development of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors: What Lessons Have We Learned? -- GIST As the Model of Paradigm Shift Towards Targeted Therapy of Solid Tumors: Update and Perspective on Trial Design -- Monoclonal Antibodies in the Treatment of Malignant Lymphomas -- Molecular Network Analysis using Reverse Phase Protein Microarrays for Patient Tailored Therapy.