TITLE PAGE -- TABLE OF CONTENTS -- LIST OF CONTRIBUTORS -- PREFACE -- EDITORS' NOTE -- PART 1: THE VISION: THE DIGITAL PATIENT-IMPROVING RESEARCH, DEVELOPMENT, EDUCATION, AND HEALTHCARE PRACTICE -- 1 THE DIGITAL PATIENT -- HEALTH, THE GOAL -- PERSONALIZED MEDICINE -- THE BEST OUTCOMES -- THE EMERGENCE OF THE DIGITAL PATIENT -- THE HUMAN PHYSIOME -- ENABLING THE DIGITAL PATIENT -- P4 MEDICINE -- CONCLUSION -- REFERENCES -- 2 REFLECTING ON DISCIPULUS AND REMAINING CHALLENGES -- INTRODUCTION -- A BRIEF CONTEXTUAL BACKGROUND AND A CALL FOR INTEGRATION: PERSONALIZED MEDICINE IS HOLISTIC -- THE MANY VERSIONS OF THE DIGITAL PATIENT: ON THE ROAD TO MEDICAL AVATARS -- DISCIPULUS: THE DIGITAL PATIENT TECHNOLOGICAL CHALLENGES AND MAIN CONCLUSIONS -- THE REMAINING CHALLENGES AND BIG DATA -- CONCLUSION -- REFERENCES -- 3 ADVANCING THE DIGITAL PATIENT -- INTRODUCTION -- THE DIGITAL PATIENT: ITS EARLY START -- ENGAGING THE DIGITAL PATIENT -- CONCLUSION -- 4 THE SIGNIFICANCE OF MODELING AND VISUALIZATION -- INTRODUCTION -- MODELING A COMPLEX SYSTEM: HUMAN PHYSIOLOGY -- MEDICAL MODELING, SIMULATION, AND VISUALIZATION -- MODES AND TYPES OF VISUALIZATION -- VISUALIZATION FOR PATIENT-SPECIFIC USEFULNESS -- CONCLUSION -- REFERENCES -- PART 2: STATE OF THE ART: SYSTEMS BIOLOGY, THE PHYSIOME, AND PERSONALIZED HEALTH -- 5 THE VISIBLE HUMAN: A GRAPHICAL INTERFACE FOR HOLISTIC MODELING AND SIMULATION -- INTRODUCTION -- EDUCATION -- MODELING -- VIRTUAL REALITY TRAINERS AND SIMULATORS -- CONCLUSION -- REFERENCES -- 6 THE QUANTIFIABLE SELF: PETABYTE BY PETABYTE -- INTRODUCTION -- SMARR'S QUANTIFIED SELF -- EXTENDING SMARR'S RESEARCH -- THE QUANTIFIED SELF-VISION, SIMPLIFIED -- CRITICISM -- CONCLUSION -- REFERENCES -- 7 SYSTEMS BIOLOGY AND HEALTH SYSTEMS COMPLEXITY: IMPLICATIONS FOR THE DIGITAL PATIENT -- INTRODUCTION -- SYSTEMS BIOLOGY -- THE INSTITUTE FOR SYSTEMS BIOLOGY.

THE COMPLEXITY INSTITUTE -- THE POTENTIAL OF SYSTEMS BIOLOGY -- CRITICISM -- CONCLUSION -- REFERENCES -- 8 PERSONALIZED COMPUTATIONAL MODELING FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS -- INTRODUCTION -- BASICS OF CARDIAC ELECTROPHYSIOLOGY -- CARDIAC MODELING ADVANCEMENTS -- REGULATION OF INTRACELLULAR CALCIUM -- FROM CELLS TO CABLES TO SHEETS TO TISSUE TO THE HEART -- WHERE CAN WE GO FROM HERE? WHAT IS THE CARDIAC MODEL IN THE DIGITAL PATIENT? -- REFERENCES -- 9 THE PHYSIOME PROJECT, openEHR ARCHETYPES, AND THE DIGITAL PATIENT -- INTRODUCTION -- MULTISCALE PHYSIOLOGICAL PROCESSES -- PHYSIOME PROJECT STANDARDS, REPOSITORIES, AND TOOLS -- ARCHETYPE SPECIALIZATION -- ARCHETYPE DEFINITION LANGUAGE -- LINKING ARCHETYPES TO EXTERNAL KNOWLEDGE SOURCES (TERMINOLOGY AND BIOMEDICAL ONTOLOGIES) -- ARCHETYPE ANNOTATIONS -- OpenEHR MODEL REPOSITORY AND GOVERNANCE -- FAST HEALTHCARE INTEROPERABILITY RESOURCES -- A DISEASE SCENARIO -- SUMMARY AND CONCLUSIONS -- REFERENCES -- 10 PHYSICS-BASED MODELING FOR THE PHYSIOME -- INTRODUCTION -- MODELING SCHEMES -- FUTURE CHALLENGES -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- 11 MODELING AND UNDERSTANDING THE HUMAN BODY WITH SwarmScript -- INTRODUCTION -- RELATED WORK -- MULTIAGENT ORGANIZATION -- DESIGNING INTERACTIVE AGENTS -- SPEAKING SwarmScript -- ANSWERING DEMAND: THE DESIGN OF SwarmScript -- GRAPH-BASED RULE REPRESENTATION -- THE SOURCE-ACTION-TARGET -- SwarmScript INTO3D -- A SwarmScript DIALOGUE -- DISCUSSION -- SUMMARY -- REFERENCES -- 12 USING AVATARS AND AGENTS TO PROMOTE REAL-WORLD HEALTH BEHAVIOR CHANGES -- INTRODUCTION -- AVATARS AND AGENTS -- USING AGENTS AND AVATARS TO PROMOTE HEALTH BEHAVIOR CHANGES -- CONCLUSION -- References -- 13 VIRTUAL REALITY AND EATING, DIABETES, AND OBESITY -- INTRODUCTION -- VIRTUAL REALITY -- CONCLUSION -- References.

14 IMMERSIVE VIRTUAL REALITY TO MODEL PHYSICAL: SOCIAL INTERACTION AND SELF-REPRESENTATION -- INTRODUCTION -- THEORY FOR IMMERSIVE VIRTUAL LEARNING SPACES -- CONCLUSION -- REFERENCES -- PART 3: CHALLENGES: ASSIMILATING THE COMPREHENSIVE DIGITAL PATIENT -- 15 A ROADMAP FOR BUILDING A DIGITAL PATIENT SYSTEM -- INTRODUCTION -- APPROACH -- BUILDING THE DIGITAL PATIENT THROUGH INTEROPERABILITY -- CONCLUSION -- ACKNOWLEDGMENT -- REFERENCES -- 16 MULTIDISCIPLINARY, INTERDISCIPLINARY, AND TRANSDISCIPLINARY RESEARCH: CONTEXTUALIZATION AND RELIABILITY OF THE COMPOSITE -- INTRODUCTION -- INTERDISCIPLINARITY AND INTERDISCIPLINARY RESEARCH -- BASE OBJECT MODELS TO SUPPORT TRANSDISCIPLINARITY AND COMPOSABILITY -- OPEN CHALLENGES ON RELIABILITY -- SUMMARY AND CONCLUSION -- REFERENCES -- 17 BAYES NET MODELING: THE MEANS TO CRAFT THE DIGITAL PATIENT -- INTRODUCTION -- OTHER INTERESTING APPLICATIONS -- CONCLUSION -- REFERENCES -- PART 4: POTENTIAL IMPACT: ENGAGING THE DIGITAL PATIENT -- 18 VIRTUAL REALITY STANDARDIZED PATIENTS FOR CLINICAL TRAINING -- INTRODUCTION -- THE RATIONALE FOR VIRTUAL STANDARDIZED PATIENTS -- CONVERSATIONAL VIRTUAL HUMAN AGENTS -- USC EFFORTS TO CREATE VIRTUAL STANDARDIZED PATIENTS -- CONCLUSION -- REFERENCES -- 19 THE DIGITAL PATIENT: CHANGING THE PARADIGM OF HEALTHCARE AND IMPACTING MEDICAL RESEARCH AND EDUCATION -- INTRODUCTION -- OVERVIEW DIGITAL MEDICINE PROJECTS -- PERSONALIZED PATIENT CARE CLINICAL USE -- RECOMMENDED EDUCATION AND TRAINING FOR VPH PROJECT PARTICIPATION -- FROM FLEXNER TO THE 2010 CARNEGIE REPORT -- SUMMARY STATEMENTS -- REFERENCES -- 20 THE DIGITAL PATIENT: A VISION FOR REVOLUTIONIZING THE ELECTRONIC MEDICAL RECORD AND FUTURE HEALTHCARE -- INTRODUCTION -- APPLICATIONS OF THE DIGITAL PATIENT AS THE EMR -- DISCUSSION -- CONCLUSION -- REFERENCES -- 21 REALIZING THE DIGITAL PATIENT -- INDEX -- MODELING AND SIMULATION.

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