FrontMatter -- Preface -- Contents -- A Risk-Characterization Framework for Decision-Making at the Food and Drugh Administration -- Summary -- 1 Introduction -- 2 A Risk-Characterization Framework -- 3 Case Study of a Mitigation-Selection Decision -- 4 Case Study of a Targeting Decision -- 5 Case Study of a Strategic-Investment Decision -- 6 Case Study of a Targeting Decision That Spans Food and Drug Administration Centers -- 7 Conclusions and Future Directions -- Appendix A: Letter Report on the Development of a Model for Ranking FDA Product Categories on the Basis of Health Risks -- Appendix B: Statement of Task for the Committee on Ranking FDA Product Categories Based on Health Consequences, Phase II -- Appendix C: Scenarios Provided by the U.S. Food and Drug Administration to the Committee on Ranking FDA Product Categories Based on Health Consequences, Phase II -- Appendix D: Biographic Information on the Committee on Ranking FDA Product Categories Based on Health Consequences, Phase II -- Appendix E: Factors Hypothesized as Important in Understanding Risk.