CONTENTS -- CONTRIBUTORS -- PART 1 Approach to the Patient with Peripheral Neuropathy -- 1. EVALUATION OF THE PATIENT WITH PERIPHERAL NEUROPATHY: THE CHALLENGES -- THE RATIONAL DIAGNOSTIC PROCESS -- SUMMARY -- 2. CLUES TO DIAGNOSIS OF PERIPHERAL NEUROPATHY: HISTORY AND EXAMINATION OF THE PATIENT -- HISTORICAL INFORMATION IMPORTANT FOR DIAGNOSIS OF PERIPHERAL NERVE DISEASE -- EXAMINING THE PATIENT WITH PERIPHERAL NEUROPATHY -- SUMMARY -- 3. ELECTRODIAGNOSTIC EVALUATION OF THE PERIPHERAL NEUROPATHY PATIENT -- TECHNIQUE -- SENSORY NERVE CONDUCTION STUDIES -- MOTOR NERVE CONDUCTION STUDIES -- ELECTROMYOGRAPHY -- PREDICTING PATHOLOGY -- THE CLINICAL NEUROPHYSIOLOGY REPORT -- CLINICAL-ELECTRODIAGNOSTIC CORRELATION -- LIMITATIONS -- CASE REPORT -- SUMMARY -- 4. EVALUATION OF THE PERIPHERAL NEUROPATHY PATIENT USING QUANTITATIVE SENSORY TESTING -- SENSORY FIBERS AND RECEPTORS -- TESTING AND ALGORITHMS -- APPLICATIONS OF QUANTITATIVE SENSORY TESTING -- SUMMARY -- 5. EVALUATION OF THE PERIPHERAL NEUROPATHY PATIENT USING AUTONOMIC REFLEX TESTS -- EVALUATION OF SUDOMOTOR FUNCTION -- EVALUATION OF CARDIOVAGAL AND ADRENERGIC FUNCTIONS -- MANAGEMENT OF ORTHOSTATIC HYPOTENSION -- SUMMARY -- 6. THE ROLE OF AUTOANTIBODY TESTING -- ANTI-GANGLIOSIDE ANTIBODIES AND ASSOCIATED NEUROPATHIES -- ANTI-GANGLIOSIDE GQ1b AND FISHER SYNDROME -- ANTI-MYELIN ASSOCIATED GLYCOPROTEIN AND ASSOCIATED NEUROPATHIES -- ANTI-HU (ANTI-NEURONAL NUCLEAR ANTIBODY, TYPE 1) AND ASSOCIATED NEUROLOGIC SYNDROMES -- ANTI-SULFATIDE ANTIBODIES AND ASSOCIATED NEUROPATHY -- OTHER ANTIBODIES -- SUMMARY -- 7. THE ROLE OF PERIPHERAL NERVE AND SKIN BIOPSIES -- NERVE BIOPSY SITES, COMPLICATIONS, AND PATTERN OF NERVE REGENERATION -- TISSUE PREPARATION -- SPECIFIC PATHOLOGIC ABNORMALITIES IDENTIFIABLE BY NERVE BIOPSY -- NEUROPATHIES WITH SUPPORTIVE ABNORMALITIES ON NERVE BIOPSY -- SKIN BIOPSIES.

8. APPROACH TO PAINFUL PERIPHERAL NEUROPATHIES -- PATHOPHYSIOLOGY -- DIFFERENTIAL DIAGNOSIS -- TREATMENT -- SUMMARY -- PART 2 Peripheral Nerve Disorders -- 9. GUILLAIN-BARRÉ SYNDROME -- HISTORY AND TERMINOLOGY -- GUILLAIN-BARRÉ SYNDROMES WITH WEAKNESS AS THE PREDOMINANT FEATURE -- GUILLAIN-BARRÉ SYNDROMES LACKING WEAKNESS AS THE PREDOMINANT FEATURE -- SUMMARY -- 10. CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY -- HISTORICAL BACKGROUND -- CLINICAL FEATURES -- CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY WITH CONCURRENT CONDITIONS -- LABORATORY FEATURES -- DIAGNOSTIC CRITERIA AND POTENTIAL LIMITATIONS -- MANAGING PATIENTS NOT FULFILLING CIDP CRITERIA -- PATHOGENESIS -- TREATMENT -- PROGNOSIS -- SUMMARY -- 11. MULTIFOCAL MOTOR NEUROPATHY -- CLINICAL FEATURES -- ELECTRODIAGNOSTIC FEATURES -- OTHER LABORATORY FEATURES -- DIFFERENTIAL DIAGNOSIS -- RESPONSE TO TREATMENT -- PATHOGENESIS -- SUMMARY -- 12. VASCULITIC NEUROPATHY -- HISTORICAL OVERVIEW -- EPIDEMIOLOGY -- CLASSIFICATION OF THE VASCULITIDES -- CLINICAL FEATURES OF VASCULITIC NEUROPATHY -- LABORATORY FEATURES -- DIFFERENTIAL DIAGNOSIS -- PATHOGENESIS -- TREATMENT -- PROGNOSIS -- SUMMARY -- 13. PERIPHERAL NEUROPATHIES ASSOCIATED WITH CONNECTIVE TISSUE DISEASES -- SYSTEMIC LUPUS ERYTHEMATOSUS -- SCLERODERMA (SYSTEMIC SCLEROSIS) -- EOSINOPHILIA-MYALGIA SYNDROME -- MIXED CONNECTIVE TISSUE DISEASE -- RHEUMATOID ARTHRITIS -- SJÖGREN'S SYNDROME -- RELAPSING POLYCHONDRITIS -- BEHÇET'S DISEASE -- SUMMARY -- 14. SARCOID PERIPHERAL NEUROPATHY -- SYSTEMIC INVOLVEMENT -- PERIPHERAL NEUROPATHIES -- PATHOGENESIS OF SARCOID NEUROPATHY -- PATIENT EVALUATION -- TREATMENT -- SUMMARY -- 15. NEUROPATHIES ASSOCIATED WITH MONOCLONAL GAMMOPATHIES -- DEFINITION OF TERMS AND INCIDENCE -- METHODS OF DETECTION -- PATIENT EVALUATION -- SPECIFIC DISORDERS ASSOCIATED WITH MONOCLONAL ANTIBODIES.

SUMMARY -- 16. TOXIC NEUROPATHIES: DRUGS, METALS, AND ALCOHOL -- NEUROTOXIC DRUGS -- METAL TOXICITY -- ALCOHOL-RELATED NEUROPATHY -- SUMMARY -- 17. PORPHYRIC NEUROPATHY -- HEME BIOSYNTHETIC PATHWAY -- THE HEPATIC PORPHYRIAS -- TOXIC PORPHYRIA -- SUMMARY -- 18. CRITICAL ILLNESS POLYNEUROPATHY AND RELATED CONDITIONS -- CRITICAL ILLNESS POLYNEUROPATHY AND RELATED NEUROPATHIC CONDITIONS -- HOPKINS SYNDROME -- SUMMARY -- 19. DIABETIC NEUROPATHIES -- CLASSIFICATION OF DIABETES -- DIAGNOSIS OF DIABETES MELLITUS -- FOCAL AND MULTIFOCAL DIABETIC NEUROPATHIES -- DIABETIC POLYNEUROPATHY -- TREATMENT OF DIABETIC POLYNEUROPATHY -- UNCOMMON NEUROPATHIES ASSOCIATED WITH DIABETES -- SUMMARY -- 20. PERIPHERAL NEUROPATHY ASSOCIATED WITH HIV INFECTION -- HISTORICAL OVERVIEW AND EPIDEMIOLOGY OF AIDS -- CLASSIFICATION OF HIV INFECTION -- PREVALENCE OF PERIPHERAL NEUROPATHY IN HIV-INFECTED PATIENTS -- PREVALENCE OF CEREBROSPINAL FLUID ABNORMALITIES IN HIV-POSITIVE INDIVIDUALS -- HIV-RELATED PERIPHERAL NEUROPATHIES -- LESS COMMON NEUROPATHIES -- SUMMARY -- 21. HEREDITARY MOTOR AND SENSORY NEUROPATHIES AND GIANT AXONAL NEUROPATHY -- CHARCOT-MARIE-TOOTH AND RELATED NEUROPATHIES -- GIANT AXONAL NEUROPATHY -- TREATMENT FOR HEREDITARY MOTOR AND SENSORY NEUROPATHIES AND GIANT AXONAL NEUROPATHY -- SUMMARY -- 22. HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES -- BACKGROUND AND HISTORY -- PROPERTIES OF THE TRK FAMILY OF NEUROTROPHIN RECEPTORS -- HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE I -- HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE II -- HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE III -- HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE IV -- HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE V -- HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY TYPE VI AND OTHER VARIANTS -- CONGENITAL INDIFFERENCE TO PAIN -- SUMMARY -- 23. FAMILIAL AMYLOID POLYNEUROPATHIES.

CLASSIFICATION OF FAMILIAL AMYLOID POLYNEUROPATHIES -- TRANSTHYRETIN AMYLOIDOSIS -- APOLIPOPROTEIN A-l AMYLOIDOSIS -- GELSOLIN AMYLOIDOSIS -- DIAGNOSIS OF AMYLOID POLYNEUROPATHY -- SUMMARY -- 24. PEROXISOMAL DEFECTS: REFSUM DISEASE AND ADRENOMYELONEUROPATHY -- REFSUM DISEASE -- X-LINKED ADRENOMYELONEUROPATHY -- SUMMARY -- 25. α-GALACTOSIDASE A DEFICIENCY: FABRY DISEASE -- CLINICAL FEATURES -- LABORATORY FEATURES -- GENETICS -- TREATMENT -- SUMMARY -- 26. LIPOPROTEIN DISORDERS: TANGIER DISEASE AND ARETALIPOPROTEINEMIA/FAMILIAL HYPORETALIPOPROTEINEMIA -- LIPIDS AND LIPOPROTEINS -- TANGIER DISEASE -- ABETALIPOPROTEINEMIA AND FAMILIAL HYPOBETALIPOPROTEINEMIA -- SUMMARY -- 27. VITAMIN DEFICIENCIES: COBALAMIN (VITAMIN B12), VITAMIN E (TOCOPHEROL), AND THIAMINE (VITAMIN B1) -- COBALAMIN DEFICIENCY -- VITAMIN E DEFICIENCY -- THIAMINE DEFICIENCY -- SUMMARY -- 28. LEPROUS NEUROPATHY -- CHARACTERISTICS OF MYCOBACTERIUM LEPRAE -- CLASSIFICATION OF LEPROSY -- CLINICAL FEATURES -- LABORATORY FEATURES -- PATHOLOGY AND IMMUNOPATHOGENESIS -- TREATMENT -- SUMMARY -- 29. NEUROPATHIES ASSOCIATED WITH ORGAN SYSTEM FAILURE, ORGAN TRANSPLANTATION, METABOLIC DISORDERS, AND CANCER -- NEUROPATHIES ASSOCIATED WITH RENAL FAILURE -- NEUROPATHIES ASSOCIATED WITH HEPATIC DISEASE -- NEUROPATHY ASSOCIATED WITH PULMONARY FAILURE -- NEUROPATHIES ASSOCIATED WITH ORGAN TRANSPLANTATION -- NEUROPATHY ASSOCIATED WITH SYSTEMIC METABOLIC ABNORMALITIES -- NEUROPATHIES ASSOCIATED WITH CANCER -- SUMMARY -- 30. ENTRAPMENT NEUROPATHIES -- PREDISPOSITION TO ENTRAPMENT NEUROPATHIES -- PATHOPHYSIOLOGY OF NERVE COMPRESSION -- MEDIAN NERVE -- ULNAR NERVE -- RADIAL NERVE -- PERONEAL NERVE -- TIBIAL NERVE -- OTHER LOWER LIMB NERVE ENTRAPMENTS -- SUMMARY -- 31. PLEXOPATHIES -- PATHOLOGY AND PATHOPHYSIOLOGY OF PLEXUS LESIONS -- THE CERVICAL PLEXUS -- THE BRACHIAL PLEXUS -- THE LUMBOSACRAL PLEXUS.

SUMMARY -- INDEX -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Z.