FrontMatter -- Preface -- Acknowledgments -- Contents -- Summary -- 1 The Select Agent Regulations -- 2 Challenges of Predicting Pathogenicity from Sequence -- 3 A Proposal for Consideration: Sequence-Based Classification of Select Agents -- 4 Committee Findings and Conclusions -- References -- Appendix A: Statement of Task -- Appendix B: Committee Member and Staff Biographies -- Appendix C: HHS and USDA Select Agents and Toxins -- Appendix D: 2009 Workshop Agenda -- Appendix E: Applicability of the Select Agent Regulations to Issues of Synthetic Genomics -- Appendix F: Summary of Relevant Legislation, Regulation, and Guidance -- Appendix G: Influenza A and SARS-CoV -- Appendix H: Virus-Host Interactions -- Appendix I: Botulinum Neurotoxin, B. Anthracis and Variola Virus -- Appendix J: Pathogenicity Acquisition -- Appendix K: Interactions of Infectious Agents with the Host -- Appendix L: Near-Term Milestones for Consideration -- Appendix M: Executive Order: Optimizing the Security of Biological Select Agents and Toxins in the United States.