Preface -- Abbreviations -- Contents -- Summary -- 1 The National Nanotechnology Initiative and the Genesis of the Environmental, Health, and Safety Strategy -- 2 Elements of an Effective Nanotechnology Risk-Research Strategy -- 3 Evaluation of the Federal Strategy -- 4 Review of High-Priority Research Topics, Research Needs, and Gap Analysis -- 5 Conclusions and Recommendations -- Appendix A: Biographic Information on the Committee for Review of the Federal Strategy to Address Environmental, Health, and Safety Research Needs for Engineered Nanoscale Materials -- Appendix B: Statement of Task -- Appendix C: Workshop Agendas of the National Research Council Committee for Review of the Federal Strategy to Address Environmental, Health, and Safety Research Needs for Engineered Nanoscale Materials -- Appendix D: National Nanotechnology Initiative Strategy for Nanotechnology-Related Environmental, Health, and Safety Research.