FrontMatter -- Preface -- Acknowledgment of Review Participants -- Contents -- Summary -- 1 Introduction -- 2 Historical Background -- 3 The Coeur d'Alene System -- 4 Remedial Investigation Assessment -- 5 Human Health Risk Assessment in the Coeur d'Alene River Basin -- 6 Human Health Risk Assessment: Lead Exposure and Uptake- Use of the IEUBK Model -- 7 Ecologic Risk Assessment -- 8 Remediation Objectives and Approaches -- 9 Mining Megasites: Lessons Learned -- Appendixes -- Appendix A Statement of Task and Committee Biosketches -- Appendix B Evaluation of the Methodology to Determine Background Concentrations in the Lower Basin -- Appendix C Detailed Comments on the Integrated Exposure Uptake Biokinetic Implementation Code -- Appendix D Procedures Used in Model Comparisons -- Appendix E Crustal Element Analyses for Following Soil Lead Transport -- Appendix F Assessment of the Probabilistic Model for Estimating Metal Loading and Effectiveness of Remedial Action.