FrontMatter -- Preface -- Acknowledgment of Members of the Astro2010 Infrastructure Study Groups -- Acknowledgment of Reviewers -- Contents -- Dedication: John Huchra -- Executive Summary -- 1 2020 Vision -- 2 On the Threshold -- 3 Partnership in Astronomy and Astrophysics: Collaboration, Cooperation, Coordination -- 4 Astronomy in Society -- 5 Sustaining the Core Research Program -- 6 Preparing for Tomorrow -- 7 Realizing the Opportunities -- Appendixes -- Appendix A: Summary of Science Frontiers Panels' Findings -- Appendix B: Summary of Program Prioritization Panels' Recommendations -- Appendix C: The Cost, Risk, and Technical Readiness Evaluation Process -- Appendix D: Mid-Scale Project Descriptions -- Appendix E: Statement of Task and Scope -- Appendix F: Acronyms -- Index.