I. Introduction : Historical overview -- The man with the golden arm -- Intellectual property protection -- Forensic science and detection -- Data falsification in science -- Cryptography (and SETI) -- Randomness -- II. Overview of the design inference : The explanatory filter -- The logic of the inference -- Case study, the creation-evolution controversy -- From design to agency -- III. Probability theory : The probability of an event -- Events -- Background information -- Likelihood -- The best available estimate -- Axiomization of probability -- IV. Complexity theory : The complexity of a problem -- Problems and resources -- Difficulty and its estimation -- Axiomization of complexity -- Calibration through complexity bounds -- Information measures -- RMS measures -- Technical supplement on RMS measure -- V. SSpecification : Patterns -- The requisite precondition -- Detachability -- Specification defined -- Pyramids and presidents -- Information tucked within information -- Prediction -- Increasing the power of a complexity measure -- Caputo revisited -- Randomness revisited -- VI. Small probability : Probabilistic resources -- The generic chance elimination argument -- The magic number 1/2 -- Statistical signigcance testing -- Local and universal small probabilities -- The inflationary fallacy -- The law of small probability.