Neurodegeneration : The Molecular Pathology of Dementia and Movement Disorders.
Title:
Neurodegeneration : The Molecular Pathology of Dementia and Movement Disorders.
Author:
Dickson, Dennis.
ISBN:
9781444341225
Personal Author:
Edition:
2nd ed.
Physical Description:
1 online resource (497 pages)
Contents:
Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders -- Contents -- List of Contributors -- Preface -- List of Abbreviations -- Part 1: Introduction: Basic Mechanisms of Neurodegeneration -- 1: Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders -- 2: Cell Death and Neurodegeneration -- 3: Oxidative Stress and Balance in Neurodegenerative Diseases -- 4: Protein Aggregation in Neurodegeneration -- 5: Protein Degradation in Neurodegeneration: The Ubiquitin Pathway -- 6: Genetics of Neurodegeneration -- 7: Transgenic Animal Models of Proteinopathies -- Part 2: Alzheimer's Disease and Aging -- 8: Clinical Aspects of Alzheimer's Disease -- 9: Genetics of Alzheimer's Disease -- 10: Neuropathology of Alzheimer's Disease and its Variants -- 11: Amyloid-β Production -- 12: Elimination of Amyloid β from the Brain, its Failure in Alzheimer's Disease and Implications for Therapy -- Part 3: Tauopathies -- 13: Introduction to the Tauopathies -- 14: Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 -- 15: Progressive Supranuclear Palsy and Corticobasal Degeneration -- 16: Pick's Disease -- 17: Argyrophilic Grain Disease -- 18: Parkinsonism-Dementia Complex of Guam -- 19: Postencephalitic Parkinsonism -- Part 4: Synucleinopathies -- 20: Introduction to α-Synucleinopathies -- 21: Parkinson's Disease -- 22: Dementia with Lewy Bodies and Parkinson's Disease Dementia -- 23: Lewy Bodies in Conditions other than Disorders of α-Synuclein -- 24: Multiple System Atrophy -- Part 5: Trinucleotide Repeat Disorders -- 25: Introduction to Trinucleotide Repeat Diseases -- 26: Huntington's Disease -- 27: Spinocerebellar Ataxias -- 28: Friedreich's Ataxia -- 29: Dentatorubral- pallidoluysian Atrophy -- 30: Spinal and Bulbar Muscular Atrophy -- Part 6: Prion Disorders.
31: Introduction to Prion Disorders -- 32: Sporadic Creutzfeldt-Jakob Disease -- 33: Genetic Creutzfeldt-Jakob Disease -- 34: Fatal Familial and Sporadic Insomnia -- 35: A New Prion Disease: Protease -Sensitive Prionopathy -- 36: Variant Creutzfeldt-Jakob Disease -- 37: Gerstmann-Sträussler-Scheinker Disease -- 38: Kuru -- 39: Iatrogenic Creutzfeldt-Jakob Disease -- Part 7: Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis/Motor Neuron Disease -- 40: Introduction -- 41: Frontotemporal Lobar Degeneration with TDP-43 Pathology -- 42: Neuronal Intermediate Filament Inclusion Disease -- 43: Frontotemporal Lobar Degeneration with FUS Immunoreactive Inclusions -- 44: Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis and Spinal Muscular Atrophy -- Part 8: Other Neurodegenerative Disorders -- 45: Introduction: Genetic Analysis as a Lumper and Splitter in Neurodegenerative Disease -- 46: Inherited Amyloidoses and Neurodegeneration: Familial British Dementia and Familial Danish Dementia -- 47: Neurodegeneration with Brain Iron Accumulation -- 48: Familial Encephalopathy with Neuroserpin Inclusion Bodies -- 49: Hereditary Ferritinopathies -- Index.
Abstract:
Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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