CANCER AND STEM CELLS -- NOTICE TO THE READER -- Contents -- Preface -- Cancer Stem Cells: A Definition -- Abstract -- Synonyms -- Abbreviations -- Definition -- Characteristics -- Identification -- Acknowledgements -- References -- Mathematical Modeling of Stem CellsRelated to Cancer -- Abstract -- Introduction -- Continuous Mathematical Models -- Continuous Models of Periodic Hematological Diseases -- A Continuous Model of Stem Cell and Cancer Stem Cell Proliferation,Differentiation and Maturation -- Interaction between Quiescent and Proliferating Stem Cells Described by aContinuous Mathematical Model -- A Continuous Mathematical Model for Nuclear Factor κB ComplexDeterminating the Proliferation of Adult Neural Stem Cells -- Discrete Mathematical Models -- A Discrete Cellular Automaton Model of Stem Cells and TissueHomeostasis -- An Agent Based Model of Stem Cell and Non-Stem Cell Tissue Dynamics -- Conclusion -- Acknowledgments -- References -- Where Do Cancer Stem CellsCome From? -- Introduction -- Cancer Stem Cell Hypothesis -- Adult Tissue Stem Cells -- Stem Cells within the Bone Marrow Have theAbility to Regenerate Multiple Tissue Types -- Similarity between the Somatic (Tissue) StemCells and Cancer Stem Cells -- The Niche and Stem Cell's Fate -- Cancer Stem Cells Originating fromBone Marrow -- Conclusion -- References -- Mismatch Repair Deficiencies andOrigin of Cancer Stem Cells -- Abstract -- 1. Introduction -- 1.1. DNA Repair Pathways -- 1.2. MMR Deficiency and Stem Cell Defects -- 1.3. Cancer Stem Cell Therapy -- 1.4. Conclusion -- References -- Cancer Stem Cells in HematologicalMalignancies -- Abstract -- Abbreviations -- 1. Introduction -- 2. CSCs in Chronic and Acute Leukemias -- 2.1. LSCs in Chronic Myelogeneous Leukemia (CML) -- 2.2. LSCs in Acute Myelogeneous Leukemia (AML) -- 2.3. Lymphoid LSCs.

3. Cancer Stem Cell Concepts and Questions:Lessons from Leukemia -- 3.1. 'Cell of Origin' and the CSC -- 3.2. CSCs: Are They Rare? -- 4. Therapeutic Implications of DrugResistant CSCs -- 5. Eradication of LSCs -- Conclusion -- References -- Stem Cells in Solid Tumors -- Abstract -- Introduction -- Cancer Stem Cells in Human Solid Tumors -- Stem Cells in Mouse Models of Cancer -- Linking Molecular Stem Cell Pathways toCancer -- Stem Cell Niche and Cancer -- Anticancer Therapeutics Based on theCancer Stem Cell Model -- Conclusion -- Acknowledgements -- References -- Cancer Stem Cells and Metastasis -- Abstract -- Introduction -- Poor Prognosis, Primary Tumors and pCSCs -- pCSC Origins and Metastasis -- Metastatic Cancer Stem Cells -- The (PRE)-Metastatic Niche and mCSCs -- Metastasis, CSCs and Chemotherapy -- Self-Renewal and Differentiation -- Metastasis Niche -- Reactivation -- Conclusion -- References -- Exercise, Stem Cells and Cancer -- Introduction -- Exercise and Stem Cells -- Exercise and Endothelial Progenitor Cells -- Exercise and Hematopoietic Stem Cells (HSCs) -- Potential Mechanisms for the Mobilization of EPCs and HSCs -- Exercise and Myogenic Satellite Cells -- Exercise and Cancer -- Physical Activity during Cancer Pre-Diagnosis Period -- Physical Activity during Cancer Post-Diagnosis -- Physical Activity, Cancer and Murine Tumour Models -- Perspectives -- References -- Human Adult Stem Cells as Targets forCancer Stem Cells:Evolution -- Oct-4 Gene and Cell-to-CellCommunication -- Abstract -- Introduction: The Complexicity of a ComplicatedDisease -- The Interaction of Biological and CulturalEvolutionary Factors -- No One Appendage Describes an Elephant,Nor Does Only One Thing Cause Cancer! -- From Single Cell Organisms to Multi-Cellular Organisms: Cancer as the"Faustian Bargain" We Paid for Our Survival.

Stem Cells, Cell Communication andDevelopmen -- The Stem Cell or De-DifferentiationHypothesis of Carcinogenesis -- Stem Cells, the Multi-Step, Multi-Mechanism Carcinogenic Process ofInitiation, Promotion and Progression -- The Mutation or Epigenetic Theories ofCarcinogenesis -- Oncogenes, Tumor Suppressor Genes, andCancer Cells -- Adult Stem Cells as the Targets forCarcinogenic Initiation -- Cancer Stem Cells:A Re-Discovery of an Old Idea -- Dietary Modulation of Normal and Cancer StemCell Pools: A View of How Diet, Systems View ofCell Biology, and the Risk to Cancer Interact -- Why Dogs and Cows Caused Human Prostateand Breast Cancers: The Interaction ofBiological and Cultural Evolution, Diet, AdultStem Cells and Cancer -- Conclusion -- References -- Targeting Cancer Stem Cells -- Abstract -- Let's Talk about Cancer Stem Cells -- What Are the Best Strategies to Target CancerStem Cells? -- Conclusions -- Acknowledgements -- References -- Index.