TABLE OF CONTENTS -- Introduction and Methods Used in This Study -- INTRODUCTION AND METHODS -- The Gastrointestinal Absorption of Vitamin B[sub(12)] in Man -- 1. A REVIEW OF THE LITERATURE -- The Fecal Excretion Technique: The Heinle Test -- The Urinary Excretion Technique: The Schilling Test -- In-Vivo Measurements of Hepatic Uptake of Radioactivity: The Glass Test -- Plasma Absorption of Radiocyanocobalamin: Doscherholmen and Hagen, Booth and Mollin -- Total Body Counting -- 2.URINARY EXCRETION TESTS -- Results in Control Patients -- Results in Patients with Addison's Pernicious Anemia -- Reproducibility of the Results of the Urinary and Fecal Excretion Tests Performed Simultaneously -- Response to Intrinsic Factor in Patients with Pernicious Anemia -- Results in Patients with Total Gastrectomy -- Results in Patients with Partial Gastrectomy -- Results in Patients with Histamine-Fast Achlorhydria -- Results in Patients with Posterolateral Column Disease of the Spinal Cord -- Results in Patients with Faber's Pernicious Anemia -- Results in Patients with Various Intestinal Diseases: Regional Ileitis, Non-Tropical Sprue, and Secondary Steatorrhea -- Results in Patients with Miscellaneous Diseases -- False Positive and Negative Urinary Excretion Tests -- Results with Varying Time Intervals between the Oral Dose and the Parenteral "Flushing" Injection -- Results with Daily "Flushing" Injections for One Week -- Results with "Flushing" Doses of Varying Magnitude -- Results with Multiple "Flushing" Injections -- Results with Parenteral "Loading" Administered Simultaneously with the Oral Dose -- Results with Parenteral "Preloading" Administered 24 Hours Prior to the Oral Test -- 3. THE PLASMA ABSORPTION TEST.

Results in Control Subjects and Patients with Pernicious Anemia after Test Doses of 0.46 μg Vitamin B[sub(12)] Containing 0.5 μc Co[sup(80)] or 0.92 μg B[sub(12)] with 1.0 μc Co[sup(60)] -- Comparison of the Plasma Absorption Method and the Schilling Test -- Results of the Plasma Absorption Test Using 0.56 μg Cyanocobalamin Containing 0.25 μc Co[sup(60)] -- Scintillation Spectrometry of Co[sup(57)]B[sub(12)] in the Diagnosis of Pernicious Anemia -- Results in Patients with Partial and Total Gastrectomy -- Results in Patients with Leukemia -- Influence of Food on the Plasma Absorption of Radiocyanocobalamin -- Results with Parenteral "Loading" Injections of Non-Labeled Vitamin B[sub(12)] -- A Dual Mechanism of Vitamin B[sub(12)] Plasma Absorption -- Delay of Absorption of Radio-Labeled Cyanocobalamin in the Intestinal Wall in the Presence of Intrinsic Factor -- 4.ABSORPTION, EXCRETION, DISTRIBUTION, AND KINETICS OF INGESTED RADIOCYANOCOBALAMIN -- Investigation of the Basic Mechanism of the Schilling Test -- Distribution of Radioactivity in Man after the Oral Ingestion of Small Test Doses of Radiocyanocobalamin -- Kinetics of Ingested Radiocyanocobalamin in Man -- Miscellaneous Studies -- 5.ENZYMATIC RELEASE OF VITAMIN B[sub(12)] BOUND EITHER TO THE INTRINSIC FACTOR OR IN THE WALL OF THE SMALL INTESTINE -- Release of Vitamin B[sub(12)] from the Intrinsic Factor -- Experiments Using Human Gastric Juice as a Source of Intrinsic Factor -- Experiments Using Rat Stomach Homogenate as a Source of Intrinsic Factor -- Experiments Using Hog Stomach IFC as a Source of IF -- Release of Co[sup(57)]B[sub(12)] from Its Binding in the Intestinal Wall -- Characterization of the Ultrafiltrable Radioactivity -- 6.TRANSPORT OF B[sub(12)] IN THE BLOOD -- Determination of Vitamin B[sub(12)] Serum Binding Capacity by Ultrafiltration.

7.ALTERATION OF HEPATIC STORAGE OF RADIOCYANOCOBALAMIN -- 8.SUMMARY -- BIBLIOGRAPHY -- INDEX -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W.