Biology of the NPY family of peptides, their receptors and processing enzymes -- Evolutionary perspective on the NPY-PYY-PP peptides and their receptors -- Function, distribution and molecular pharmacology of NPY-family receptors -- NPY processing in neuronal and non-neuronal tissues by proconvertases -- Dipeptidyl-peptidase IV and aminopeptidase P: molecular switches of NPY/PYY receptor affinities -- The NPY family of peptides in immune disorders and inflammation -- NPY, NPY receptors and DPPIV in innate immunity and autoimmune disorders -- NPY and phagocytic cell functions -- NPY in allergic and respiratory disorders -- NPY analgesia: moving from acute to chronic pain -- The NPY family of peptides and angiogenesis -- NPY as a mediator of neurogenic angiogenesis and revascularization of ischemic tissues -- NPY-induced angiogenesis in retinopathy and wound healing -- NPY in vascular inflammation, remodeling and atherosclerosis -- The NPY family of peptides as growth factors in neurodegenerative diseases and tumor biology -- NPY as a pleiotropic growth factor -- NPY and Hippocampal Neurogenesis -- NPY family of peptides in neural crest-derived tumors -- NPY family of peptides in endocrine, breast and prostate tumors -- Summary -- Future directions and therapeutic perspectives for NPY/PYYbased anti-inflammatory and tumor suppressor drugs.