Antimicrobial Therapy in Veterinary Medicine -- Copyright -- Contents -- Contributors -- Preface -- Important Notice -- Abbreviations -- Section I General Principles of Antimicrobial Therapy -- 1 Antimicrobial Drug Action and Interaction: An Introduction -- Spectrum of Activity of Antimicrobial Drugs -- Mechanisms of Action of Antimicrobial Drugs -- Antibacterial Drug Interactions: Synergism, Antagonism, and Indifference -- Bibliography -- 2 Antimicrobial Susceptibility Testing Methods and Interpretation of Results -- Antimicrobial Susceptibility Testing Methods -- Interpretation of Susceptibility Test Results -- Other Susceptibility Testing Methods -- Summary -- Bibliography -- 3 Antimicrobial Resistance and Its Epidemiology -- Introduction -- Types of Antimicrobial Resistance -- Acquisition of Antimicrobial Resistance -- The Effects of Antimicrobial Use on the Spread and Persistence of Resistance -- Antimicrobial Resistance and Public Health -- Nosocomial Infection and Antimicrobial Resistance in Veterinary Hospitals -- The Control of Antimicrobial Resistance -- Bibliography -- 4 Principles of Antimicrobial Drug Bioavailability and Disposition -- Routes of Administration -- Applied Clinical Pharmacokinetics -- Bibliography -- 5 The Pharmacodynamics of Antimicrobial Agents -- Introduction -- Interpreting the MIC from a Clinical Perspective -- Understanding the Drug Response -- Understanding the Exposure-Response Relationship -- PK/PD and Dose Predictions: Putting It All Together -- Conclusion -- Bibliography -- 6 Principles of Antimicrobial Drug Selection and Use -- Risks Associated with Antimicrobial Treatment -- Factors Determining Choice of Antibiotic -- Principles of Antimicrobial Treatment -- Bibliography -- 7 Antimicrobial Stewardship in Animals -- Introduction -- What Is "Prudent Use" of Antimicrobials?.

What Is Antimicrobial Stewardship? -- Considerations in Facilitating Antimicrobial Stewardship -- Conclusion -- Bibliography -- Section II Classes of Antimicrobial Agents -- 8 Beta-lactam Antibiotics: Penam Penicillins -- Introduction to Beta-lactam Antibiotics -- Bibliography -- Penam Penicillins -- Group 1 Benzyl Penicillin and Long-Acting Parenteral Forms -- Bibliography -- Group 2 Orally Absorbed Penicillins -- Group 3 Antistaphylococcal Isoxazolyl Penicillins: Cloxacillin, Dicloxacillin, Methicillin, Nafcillin, and Oxacillin -- Bibliography -- Group 4 Extended-Spectrum Penicillins: Aminobenzyl Penicillins: Ampicillin and Amoxicillin -- Bibliography -- Group 4 Extended-Spectrum Penicillins: Amidopenicillins: Mecillinam -- Group 5 Antipseudomonal Penicillins: Carboxypenicillins: Carbenicillin and Ticarcillin -- Group 5 Antipseudomonal Penicillins: Ureidopenicillins: Azlocillin, Mezlocillin, and Piperacillin -- Bibliography -- Group 6 Beta-lactamase-Resistant Penicillins: Temocillin -- Bibliography -- 9 Beta-lactam Antibiotics: Cephalosporins -- General Considerations -- Bibliography -- Group 1 First-Generation Cephalosporins: Cefacetrile, Cephaloridine, Cefazolin, Cephapirin, Cephradine, and Cephalothin -- Bibliography -- Group 2 Oral First-Generation Cephalosporins: Cefadroxil, Cephradine, Cephalexin, and Cephaloglycin -- Bibliography -- Group 3 Second-Generation Parenteral Cephalosporins: Cefaclor, Cefoxitin, Cefmetazole, Cefotetan, Cefuroxime, and Cefamandole -- Bibliography -- Group 4 Third-Generation Parenteral Cephalosporins: Cefmenoxime, Cefotaxime, Cefovecin, Ceftizoxime, Ceftriaxone, Ceftiofur, and Latamoxef -- Bibliography -- Group 5 Third-Generation Oral Cephalosporins: Cefetamet, Cefixime, and Cefpodoxime -- Bibliography -- Group 6 Antipseudomonal Parenteral Cephalosporins: Cefoperazone, Cefsulodin, and Ceftazidime -- Bibliography.

Group 7 Fourth-Generation Parenteral Cephalosporins: Cefepime, Cefpirome, and Cefquinome -- Bibliography -- 10 Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams -- Beta-lactamases and Beta-lactamase Inhibitors: Clavulanic Acid, Sulbactam, and Tazobactam -- Bibliography -- Bibliography -- Bibliography -- Bibliography -- Carbapenems: Imipenem-Cilastatin, Meropenem, and Biapenem -- Bibliography -- Monobactams: Aztreonam -- Bibliography -- Tribactams -- 11 Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin -- Polymyxins -- Bibliography -- Glycopeptides: Vancomycin, Teicoplanin, and Avoparcin -- Bibliography -- Bibliography -- Bibliography -- Bacitracin -- Bibliography -- Fosfomycin -- Bibliography -- 12 Lincosamides, Pleuromutilins, and Streptogramins -- Lincosamides: Lincomycin, Clindamycin, and Pirlimycin -- Bibliography -- Pleuromutilins: Tiamulin and Valnemulin -- Bibliography -- Streptogramins -- Bibliography -- Bibliography -- 13 Macrolides, Azalides, and Ketolides -- Bibliography -- Macrolides Approved for Veterinary Use: Erythromycin, Tylosin, Spiramycin, Tilmicosin, Tulathromycin, Gamithromycin, Tildipirosin, and Tylvalosin -- Bibliography -- Bibliography -- Bibliography -- Bibliography -- Bibliography -- Bibliography -- Bibliography -- Bibliography -- Advanced-Generation Macrolide Antibiotics: Roxithromycin, Clarithromycin, and Azithromycin -- Bibliography -- Ketolides -- Bibliography -- 14 Aminoglycosides and Aminocyclitols -- General Considerations -- Bibliography -- Streptomycin/Dihydrostreptomycin -- Bibliography -- Dihydrosteptamine Aminoglycosides:Neomycin Group -- Bibliography -- Kanamycin Group -- Bibliography -- Bibliography -- Bibliography -- Bibliography -- Spectinomycin -- Bibliography -- Tobramycin -- Bibliography -- 15 Tetracyclines -- Glycylcyclines -- Bibliography.

16 Chloramphenicol, Thiamphenicol, and Florfenicol -- Chloramphenicol -- Bibliography -- Thiamphenicol -- Bibliography -- Florfenicol -- Bibliography -- 17 Sulfonamides, Diaminopyrimidines, and Their Combinations -- Sulfonamides -- Bibliography -- Antibacterial Diaminopyrimidines: Aditoprim, Baquiloprim, Ormetoprim, and Trimethoprim -- Bibliography -- Antibacterial Diaminopyrimidine-Sulfonamide Combinations -- Bibliography -- Antiprotozoal Diaminopyrimidines -- Bibliography -- 18 Fluoroquinolones -- Introduction -- Bibliography -- 19 Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others -- Ionophore Antibiotics -- Bibliography -- Nitrofurans -- Bibliography -- Nitroimidazoles -- Bibliography -- Rifamycins -- Bibliography -- Oxazolidinones -- Bibliography -- Carbadox -- Bibliography -- Fusidic Acid -- Bibliography -- Isoniazid -- Bibliography -- Mupirocin -- Bibliography -- Methenamine -- Novobiocin -- Bibliography -- 20 Antifungal Chemotherapy -- Antifungal Susceptibility Testing -- Antifungal Drug Resistance -- Pharmacodynamics of Antifungal Agents -- Antifungal Drugs for Systemic Administration -- Antifungal Drugs for Topical Application -- Bibliography -- Section III Special Considerations -- 21 Prophylactic Use of Antimicrobial Agents, and Antimicrobial Chemotherapy for the Neutropenic Patient -- Prophylactic or Metaphylactic Use of Antibiotics in Livestock -- Bibliography -- Antimicrobial Prophylaxis for Surgery -- Bibliography -- Management of Infections Associated with Neutropenia in the Dog and Cat -- Bibliography -- 22 Performance Uses of Antimicrobial Agents and Non-antimicrobial Alternatives -- History -- Mechanism of Action -- Regulatory Oversight -- Usage Practices and Benefits -- Public Health Issues of Antibiotic Resistance -- Judicious Use -- Alternatives to Performance Uses -- Bibliography.

23 Antimicrobial Therapy of Selected Organ Systems -- Antimicrobial Therapy of Osteomyelitis, Septic Arthritis, and Septic Tenosynovitis -- Bibliography -- Infections of the Eyes: Conjunctivitis, Keratitis, and Endophthalmitis -- Bibliography -- Bacterial Meningitis -- Bibliography -- Urinary Tract Infections -- Bibliography -- 24 Antimicrobial Therapy of Selected Bacterial Infections -- Anaerobic Infections -- Bibliography -- Brucella -- Bibliography -- Atypical Mycobacteria -- Bibliography -- Mycoplasma -- Bibliography -- Nocardia -- Bibliography -- Leptospira and Leptospirosis -- Bibliography -- 25 Antimicrobial Drug Residues in Foods of Animal Origin -- Regulation of Veterinary Drug Residues -- Residue Monitoring Programs -- Causes and Incidence of Residue Violations -- Other Effects of Drug Residues in Food on Human Health -- Preventing Residues: The Food Animal Residue Avoidance Databank -- Conclusion -- Bibliography -- 26 Regulation of Antimicrobial Use in Animals -- Human Food Safety Related to Hazards from Veterinary Drug Residues -- Human Food Safety Related to Risk for Spreadof Antimicrobial Resistance from Animals -- Management of Antimicrobial Resistance -- Monitoring and Surveillance -- Conclusion -- Bibliography -- Section IV Antimicrobial Drug Use in Selected Animal Species -- 27 Antimicrobial Drug Use in Horses -- Common Bacterial Pathogens of Horses and Their Typical Susceptibility Patterns -- Minimum Inhibitory Concentration versus Breakpoint-What Is the Difference? -- Causes of Treatment Failure -- Pharmacodynamic Properties of Antimicrobial Agents -- Route of Administration -- Adverse Effects -- Recommendations for Specific Disorders of Microorganisms -- Bibliography -- 28 Antimicrobial Drug Use in Dogs and Cats -- Antimicrobial Drug Chemotherapy -- Antimicrobial Drug Classes and Treatment of Resistant Bacterial Infections.

Drug Formulations.