Cover -- Title -- Copyright -- Contents -- Introduction -- Chapter 1: The History oF Pharmaceuticals -- Medicines of Ancient Civilizations -- Pharmaceutical Science in the 16th and 17th Centuries -- Pharmacopoeia -- Pharmacology -- Isolation and Synthesis of Compounds -- Discovery of Antiseptics and Vaccines -- Edward Jenner -- Improvement in Drug Administration -- New Classes of Pharmaceuticals -- Transitions in Drug Discovery -- Early Efforts in the Development of anti-Infective Drugs -- Discovery of Penicillin -- Isolation of Insulin -- Identification of Vitamins -- Emergence of Modern Diseases and Treatment -- Hypertension -- Early Progress in Cancer Drugdevelopment -- The Pharmaceutical Industry in the Modern Era -- Emergence of the Biopharmaceutical Industry -- Treating Diabetes -- Chapter 2: drug Discovery and Development -- Research and Discovery -- Contribution of Scientific Knowledgeto Drug Discovery -- Drug Screening -- Sources of Compounds -- Lead Chemical Identification -- Taxol and the Pacific Yew -- Strategies For Drug Design and Production -- Structure-Activity Relationship -- Computer-Aided Design of Drugs -- Combinatorial Chemistry -- Synthetic Human Proteins -- Personalized Medicine -- Chapter 3: Drug Regulation and Approval -- Public Influence on Drug Regulation -- Objectives and Organization of Drugregulatory Agencies -- Drug Approval Process -- Food and Drug Administration -- The Investigational New Drug Application -- The New Drug Application and Biologics Licenseapplication -- Safety Testing in Animals -- Pharmacokinetic Investigation -- Dosage form Development -- Common Dosage Forms -- Obstacles in Drug Development -- Adverse Reactions -- Postmarketing Adverse Drug Events -- Drug Interactions -- Drug Patents -- Chapter 4: major Applications of biopharmaceuticals -- Use and Administration of Antibiotics.

USE AND ADMINISTRATION OF ANTIBIOTICS -- Categories of Antibiotics -- Antibiotic Resistance -- Major Antibiotics -- Vaccines -- Cytokines -- Interferon -- Monoclonal Antibodies -- Hybridoma -- Human Monoclonal Antibodies -- Cell Therapy -- Enzymes -- Hormones -- Blood Factors -- Antisense Drugs -- Peptide Therapeutics -- Chapter 5: The Future of Biopharmaceuticals -- Gene Therapy -- Pharmacogenetics -- Pharming -- Atryn -- Synthetic Biology -- Advances in Synthetic Biology -- Applications of Synthetic Biology -- Bioethical Considerations -- Conclusion -- Glossary -- Bibliography -- Index -- Back Cover.