Cell Types and Matrix -- Hepatocytes -- Signaling Pathways in Biliary Epithelial Cells -- Stellate Cells -- Kupffer Cells -- Hepatic Sinusoidal Endothelial Cells -- Extracellular Matrix -- Specific Signaling Pathways -- IL-6/gpl30/Stat3 -- Vascular Endothelial Growth Factor Signaling -- Insulin Pathway -- Nature and Function of Hepatic Tumor Necrosis Factor-? Signaling -- The Fas/FasL Signaling Pathway -- Tgf-? and the Smad Pathway in Liver Fibrogenesis -- Interferon Signaling -- CD14 and Toll Receptor -- The Wnt/?-Catenin Pathway -- Notch Signaling in Liver Disease -- Extracellular ATP: Important Developments in Purinergic Signaling -- Calcium Signaling -- MAP Kinase Pathways in the Control of Hepatocyte Growth, Metabolism and Survival -- PI3K, PTEN and Akt -- TOR Signaling and Cell Growth Control -- Peroxisome Proliferator Activated Receptors -- Transcriptional Response to cAMP in the Liver -- Heme Oxygenase System -- Nitric Oxide -- Hypoxia-Inducible Factor-1 Signaling System -- Cyclins and CDKs in Liver Diseases -- Telomeres and Telomerase: Distinctive Roles in Liver Regeneration, Cirrhosis and Carcinogenesis -- NF-?B -- Ceramide: Cell Regulation from a Lipid Perspective -- Apoptosis and Mitochondria -- Ubiquitin-Proteasome Pathway in the Pathogenesis of Liver Disease -- Biological Clock in the Liver -- Horizons -- Pharmacogenomics of Cholestatic Liver Disease -- Proteomics of Signal Transduction Pathways.