Part1 : GENETIC CAUSES AND ASSOCIATED PHENOTYPES- Lynch syndrome -- The molecular basis of Lynch-like syndrome -- Constitutional mismatch repair deficiency -- Mismatch repair proficient hereditary non-polyposis colorectal cancer -- Genetic and environmental modifiers of risk in Lynch syndrome -- ADENOMATOUS POLYPOSIS SYNDROMES- Introduction -- Familial adenomatous polyposis -- Polymerase proofreading-associated polyposis -- MUTYH-associated polyposis -- NTHL1-associated polyposis -- Germline biallelic inactivation of MMR genes (with polyposis phenotype) -- Unexplained adenomatous polyposis -- HAMARTOMATOUS POLYPOSIS SYNDROMES- Peutz-Jeghers syndrome -- Juvenile polyposis syndrome -- PTEN-hamartoma tumor syndromes -- Other hamartomatous polyposis conditions -- HEREDITARY MIXED POLYPOSIS SYNDROME -- SERRATED POLYPOSIS SYNDROME -- Part2: GENETIC DIAGNOSTICS and CLINICAL MANAGEMENT -- Genetic testing in hereditary colorectal cancer -- Universal tumor screening for Lynch syndrome -- Classification of genetic variants. Prediction models for Lynch syndrome -- Surveillance guidelines for hereditary colorectal cancer syndromes -- Surgical management of hereditary colorectal cancer syndromes -- Chemoprevention in hereditary colorectal cancer syndromes -- Immunotherapy in hereditary colorectal cancer -- The Immune Biology of Microsatellite Unstable cancer -- Hereditary colorectal cancer: Immunotherapy approaches -- Medical oncology management of hereditary colorectal cancer. Part3: REGISTRIES and DATABASES -- Databases: intentions, capabilities and limitations -- The Colon Cancer Family Registry Cohort -- The Prospective Lynch Syndrome Database -- The InSiGHT Database: An example LOVD system -- The International Mismatch Repair Consortium.