Frontmatter -- Table of Contents -- Abbreviations -- 1. Historical Introduction -- 2. History of Kuru Research -- 3. History of Prion Research -- 4. The Physical Nature of the Prion -- 5. Folding of the Recombinant Prion Protein -- 6. Structural Studies of Prion Proteins -- 7. Function of Cellular Prion Protein (PrPC) in Copper Homeostasis and Redox Signaling at the Synapse -- 8. The Scarpie Isoform of the Prion Protein PrPSe Compared to the Celluar Isoform PrPC -- 9. The Phylogeny of Mammalian and Nonmammalian Prion Proteins -- 10. Knockouts and Transgenic Mice in Prion Research -- 11. Transplantation as a Tool in Prion Research -- 12. Prion Strains -- 13. Portrait of Kuru -- 14. Portrait of Creutzfeldt-Jakob Disease -- 15. Portrait of Variant Creutzfeldt-Jakob Disease -- 16. Portrait of Gerstmann-Sträussler-Scheinker Disease -- 17. Portrait of Fatal Familial Insomnia and Sporadic Fatal Insomnia -- 18. Portrait of Scrapie in Sheep and Goat -- 19. Portrait of Bovine Spongiform Encephalopathy in Cattle and Other Ungulates -- 20. Portrait of Prion Diseases in Zoo Animals -- 21. Portrait of Chronic Wasting Disease in Deer Species -- 22. Portrait of Transmissible Mink Encephalopathy -- 23. Portrait of Transmissible Feline Spongiform Encephalopathy -- 24. Portrait of Experimental BSE in Pigs -- 25. Portrait of a Spongiform Encephalopathy in Birds and the Transmissibility of Mammalian Prior Diseases to Birds -- 26. Pathology and Genetics of Human Prion Diseases -- 27. The Pathology of Prion Diseases in Animals -- 28. Pathophysiology of Prion Diseases Following Peripheral Infection -- 29. Introduction of Surveillance for Human Prion Diseases -- 30. Clinical Findings in Human Prion Diseases -- 31. Methods for the Clinical Diagnosis of Human Prion Deseases -- 32. Introduction to Surveillance for Animal Prion Diseases.

33. Clinical Findings in Bovine Spongiform Encephalopathy -- 34. Clinical Findings in Scrapie -- 35. Diagnosis of Bovine Spongiform Encephalopathy by Immunological Methods -- 36. Epidemiology and Risk Factors of Creutzfeldt-Jakob Disease -- 37. Creutzfeldt-Jakob Disease in Germany -- 38. The Epidemiology of Kuru -- 39. The Course of the BSE Epidemic - Retrospective Epidemiological Considerations -- 40. The Causes of the BSE Epidemic -- 41. The Experimental Transmissibility of Prions and Infectivity Distribution in the Body -- 42. Iatrogenic and "Natural" Transmissibility of Prion Diseases -- 43. Inactivation in Practice - Risk Assessment and Validation for Food Gelatin -- 44. Chemical Disinfection and Inactivation of Prions -- 45. Thermal Inactivation of Prions -- 46. Prevention of Prion Diseases in the Production of Medicinal Products, Medical Devices, and Cosmetics -- 47. Prevention of the Transmission of Prion Diseases in Healthcare Settings -- 48. Precautionary Measures for Autopsies Performed in Cases of Suspected Prion Disease -- 49. Prevention of Prion Diseases in Research Laboratories -- 50. Evidence for a Link between Variant Creutzfeldt-Jakob Disease and Bovine Spongiform Encephalopathy -- 51. Risk Assessment of Transmitting Prion Diseases through Blood, Cornea, and Dura Mater -- 52. BSE Risk Assessment and Minimization -- 53. BSE Control - Internationally Recommended Approaches -- 54. Atypical Scrapie-Nor98 -- 55. Scrapie Control - Internationally Recommended Approaches -- 56. The PrP Genotype as a Marker for Scrapie Susceptibility in Sheep -- 57. Scrapie control at the National level: The Norwegian Example -- Backmatter.