Historical Perspectives -- Anti-Inflammatory Drugs in the 21st Century -- Inflammatory Mechanisms of Pathogenesis -- Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus -- Obesity, Inflammation, and Vascular Disease -- Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer -- Role of COX-2 in Inflammatory and Degenerative Brain Diseases -- Inflammation and Cardiovascular Disease: The Coxib Controversy -- Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors -- COX-2 Inhibitors And Cardiovascular Risk -- A Biological Rationale for the Cardiotoxic Effects of Rofecoxib -- Cox-2 Blockade in Cancer Prevention and Therapy -- Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade -- Strategies for Colon Cancer Prevention -- Inflammation and Neurodegenerative Disease -- NSAIDs for the Chemoprevention of Alzheimer’s Disease -- Inflammation in parkinson’s disease -- Nutrition, Inflammation and Chronic Disease -- Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases -- Nutritional Intervention in Brain Aging.