Vaccines Against Malaria: Hope in a Gathering Storm -- Copyright -- Acknowledgments -- Contents -- 1 Summary -- PROJECT CHARGE -- ORGANIZATION OF THE REPORT -- FINDINGS AND RECOMMENDATIONS -- Findings -- Recommendations -- 2 Malaria: The Deteriorating Situation -- GLOBAL EXTENT, CAUSATIVE AGENT, AND MODE OF TRANSMISSION OF MALARIA -- Life-Threatening Complications of Malaria -- HEALTH IMPACT OF MALARIA ON THE U.S. POPULATION -- U.S. Travelers Abroad -- U.S. Resident Population -- ECONOMIC AND DEVELOPMENT IMPACT OF MALARIA -- CURRENT STRATEGIES FOR MALARIA CONTROL -- Drug-Based Control Strategies -- Vector-Based Control Strategies -- THE RATIONALE FOR DEVELOPING A MALARIA VACCINE -- GOALS AND TARGET POPULATIONS FOR MALARIA VACCINES -- Preerythrocytic Vaccines -- Asexual Blood-Stage Vaccines -- Sexual (Gametocyte) Vaccines -- 3 Malaria Vaccines: The Elements for Success Are Moving into Place -- 4 Current Obstacles to Development -- THE SCIENCE -- COORDINATION -- 5 Solutions for Science -- 6 Solutions for Coordination -- PREREQUISITES FOR SUCCESS -- MODELS FOR COORDINATION AND LEADERSHIP -- IMPLEMENTING COORDINATION -- Initial Considerations -- Prioritization, Product Development, and Process Management -- Initial Efforts to Coordinate Malaria Vaccine R&D -- THE NEXT STEPS -- References -- Appendix Workshop Agenda -- AGENDA -- Summary of Agency Activities.