Contents -- Contributors -- Foreword -- Preface -- SECTION I. GENERAL PRINCIPLES -- 1 Systematics of the Genus Cryptococcus and Its Type Species C. neoformans -- 2 The History of Cryptococcus and Cryptococcosis -- 3 Biosynthesis and Genetics of the Cryptococcus Capsule -- 4 The Architecture and Antigenic Composition of the Polysaccharide Capsule -- 5 Melanin: Structure, Function, and Biosynthesis in Cryptococcus -- 6 The Cell Wall of Cryptococcus -- 7 Sexual Reproduction of Cryptococcus -- 8 Population Structure and Ecology of Cryptococcus neoformans and Cryptococcus gattii -- SECTION II. GENETICS AND GENOMICS -- 9 The Cryptococcus Genomes: Tools for Comparative Genomics and Expression Analysis -- 10 Genetic and Genomic Approaches to Cryptococcus Environmental and Host Responses -- 11 The Mating-Type Locus of Cryptococcus: Evolution of Gene Clusters Governing Sex Determination and Sexual Reproduction from the Phylogenomic Perspective -- SECTION III. SIGNALING AND VIRULENCE -- 12 G-Protein Signaling Pathways: Regulating Morphogenesis and Virulence of Cryptococcus -- 13 A Role for Mating in Cryptococcal Virulence -- 14 Sensing Extracellular Signals in Cryptococcus neoformans -- 15 Virulence Mechanisms of Cryptococcus gattii: Convergence and Divergence -- 16 Drug Resistance in Cryptococcus: Epidemiology and Molecular Mechanisms -- 17 Signaling Cascades and Enzymes as Cryptococcus Virulence Factors -- SECTION IV. ENVIRONMENTAL INTERACTIONS AND POPULATION GENETICS -- 18 Environmental Niches for Cryptococcus neoformans and Cryptococcus gattii -- 19 Cryptococcus neoformans: Nonvertebrate Hosts and the Emergence of Virulence -- 20 Cryptococcosis in Africa -- 21 Cryptococcosis in Asia -- 22 Sexual Reproduction of Cryptococcus gattii: a Population Genetics Perspective.

23 The Emergence of Cryptococcus gattii Infections on Vancouver Island and Expansion in the Pacific Northwest -- 24 Molecular Typing of the Cryptococcus neoformans/Cryptococcus gattii Species Complex -- 25 Hybridization and Its Importance in the Cryptococcus Species Complex -- SECTION V. INTERACTIONS WITH THE IMMUNE SYSTEM -- 26 The Interaction of Cryptococcus neoformans with Host Macrophages and Neutrophils -- 27 T Cell and Dendritic Cell Immune Responses to Cryptococcus -- 28 Acquired Humoral Immunity to Cryptococcus neoformans -- 29 Interactions of Capsule with Antibody and Complement -- 30 Cryptococcus Interactions with Innate Cytotoxic Lymphocytes -- SECTION VI. PATHOGENESIS OF CRYPTOCOCCOSIS -- 31 Cryptococcus neoformans: Latency and Disease -- 32 Intracellular Replication and Exit Strategies -- 33 Pulmonary Innate and Adaptive Defenses against Cryptococcus -- 34 Invasion of Cryptococcus into the Central Nervous System -- 35 Cryptococcosis in Experimental Animals: Lessons Learned -- 36 Veterinary Insights into Cryptococcosis Caused by Cryptococcus neoformans and Cryptococcus gattii -- SECTION VII. DIAGNOSIS, TREATMENT, PREVENTION, AND CLINICAL PERSPECTIVES -- 37 Cryptococcosis in Transplant Recipients -- 38 Cryptococcosis in AIDS -- 39 Antifungal Trials: Progress, Approaches, New Targets, and Perspectives in Cryptococcosis -- 40 Vaccines and Antibody Therapies from Cryptococcus neoformans to Melanoma -- 41 Diagnostic Approach Based on Capsular Antigen, Capsule Detection, β-Glucan, and DNA Analysis -- 42 Management of Cryptococcal Meningoencephalitis in Both Developed and Developing Countries -- 43 Public Health Importance of Cryptococcal Disease: Epidemiology, Burden, and Control -- 44 Clinical Perspectives on Cryptococcus neoformans and Cryptococcus gattii: Implications for Diagnosis and Management -- Index -- A -- B -- C -- D -- E -- F -- G.

H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z.