Front Matter -- Reviewers -- Preface -- Contents -- Acronyms and Abbreviations -- Summary -- 1 Introduction -- 2 Governance and Conduct of Studies -- 3 Evidence Base and Methods for Studying Health Effects -- 4 Methods for Investigating Addictive Potential -- 5 Methods for Studying Risk Perception and Risk Communication -- 6 Decision Making and Oversight of MRTP Studies: Findings and Recommendations -- Appendix A: Section 911 of the Family Smoking Prevention and Tobacco Control Act of 2009 -- Appendix B: Chapters 1 and 2 from *Evaluation of Biomarkers andSurrogate Endpoints in Chronic Disease* -- [Appendix B] 1 Introduction -- [Appendix B] 2 Review: Evaluating and Regulating Biomarker Use -- Appendix C: Committee Biographies -- Appendix D: Meeting Agendas.