The Laboratory Bench -- Introduction: Inflammatory bowel disease: from bench to bedside -- The changing faces of Crohn’s disease and ulcerative colitis -- Genetics of inflammatory bowel disease -- Experimental mouse models of inflammatory bowel disease: new insights into pathogenic mechanisms -- The normal intestinal mucosa: a state of ‘controlled inflammation’ -- The lymphocyte-epithelial-bacterial interface -- The mucosal inflammatory response. Cytokines and chemokines -- Role of the microcirculation in chronic gut inflammation -- Remission, relapse, intestinal healing and repair -- Antibodies in the exploration of inflammatory bowel disease pathogenesis and disease stratification -- Pathophysiology of inflammatory bowel disease: the effect of inflammation on intestinal function -- Systemic consequences of intestinal inflammation -- The Bedside -- Understanding symptoms and signs in inflammatory bowel disease -- Clinical course and complications of ulcerative colitis and ulcerative proctitis -- Clinical features and complications of Crohn’s disease -- Mechanisms of systemic inflammation associated with intestinal injury -- Pathology of inflammatory bowel disease: a critical appraisal in diagnosis and management -- An endoscopic and histologic perspective of diagnosis: when, where, and what to do -- Radiologic (radiographic) and imaging features of ulcerative colitis and Crohn’s disease -- New diagnostic approaches in inflammatory bowel disease -- Differential diagnosis of colitis -- ‘Disease management’ in chronic medical conditions -- Pharmacoeconomics and inflammatory bowel disease -- Measuring quality of life in inflammatory bowel disease -- Clinical pharmacology in inflammatory bowel disease: optimizing current medical therapy -- Multi-site therapeutic modalities for inflammatory bowel diseases — mechanisms of action -- Targeted therapies for inflammatory bowel disease -- Role of antibiotics and probiotics in the management of inflammatory bowel disease -- Nutrition in inflammatory bowel disease -- Medical management of ulcerative colitis -- Surgical management of ulcerative colitis -- Pouchitis: clinical characteristics and management -- Medical therapy for Crohn’s disease -- Surgery for Crohn’s disease -- Postoperative prevention of recurrence of Crohn’s disease -- The molecular pathology of inflammatory bowel disease-associated neoplasia and preneoplasia -- Dysplasia in inflammatory bowel disease: clinical pathology and current surveillance methods -- Hepatobiliary disorders -- Articular and ocular complications of inflammatory bowel disease -- Cutaneous manifestations of inflammatory bowel disease -- Fertility and pregnancy in inflammatory bowel disease -- Special considerations in the diagnosis and management of inflammatory bowel disease in the pediatric age group -- Microscopic colitis: collagenous and lymphocytic colitis -- Colon ischemia -- Diversion colitis -- Pseudomembranous colitis and Clostridium difficile infection -- Infectious colitis -- Human Immunodeficiency virus and inflammatory bowel disease -- Bone metabolism and inflammatory bowel disease -- Back to the Laboratory Bench -- Epilogue: Bench to bedside and back to bench.