Contents -- 1. The Need for New Vaccines -- 1.1 Vaccines as Evolutionary Tools: The Virulence-Antigen Strategy -- Acknowledgements -- References -- 1.2 Economic Perspectives on Vaccine Needs -- Acknowledgments -- References -- 1.3 Future Immunization Strategies - Considerations from the Public Health View -- References -- 1.4 The New Pertussis Vaccines -- References -- 2. General Principles of Immunology -- 2.1 Basic Principles of Immunity Against Intracellular Bacteria and Protozoa -- Acknowledgements -- References -- 2.2 Viral Immunity and Vaccine Strategies -- Acknowledgements -- References -- 2.3 Broadly Reactive HLA Restricted T Cell Epitopes and Their Implications for Vaccine Design -- Acknowledgements -- References -- 2.4 Quantitative Considerations in the Design of Vaccination Strategies Against Pathogens Uniquely Susceptible to Cell-Mediated Attack -- References -- 2.5 The Impact of the Type 1 and Type 2 T Helper Cell Concept on Novel Vaccine Design with Emphasis on Protection Against Leishmania Parasites -- Acknowledgements -- References -- 3. General Principles of Vaccinology -- 3.1 Modern Adjuvants. Functional Aspects -- References -- 3.2 Biodegradable Microspheres as Vehicles for Antigens -- References -- 3.3 Peptide Based Vaccines -- References -- 3.4 Recombinant Bacteria as Vaccine Carriers of Heterologous Antigens -- References -- 3.5 Genetic Detoxification of Bacterial Toxins -- References -- 3.6 Recombinant Virus as Vaccination Carrier of Heterologous Antigens -- References -- 3.7 Naked DNA Vaccination -- References -- 3.8 Oral Vaccination, Mucosal Immunity and Oral Tolerance with Special Reference to Cholera Toxin -- Acknowledgements -- References -- 4. Specific Vaccination Strategies -- 4.1 Helicobacter pylori: Pathogenic Determinants and Strategies for Vaccine Design -- Acknowledgements -- References.

4.2 Malaria Vaccination -- Acknowledgements -- References -- 4.3 Vaccination Against Schistosomiasis: Concepts and Strategies -- References -- 4.4 AIDS Vaccination -- References -- 4.5 Vaccination Therapy Against Autoimmune Diseases -- Acknowledgements -- References -- Contributors.