Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
Title:
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
Author:
Kesarwani, Meenu
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (609 seconds)
Series:
Cancer Research
General Note:
Title from resource description page
Abstract:
Here, we describe protocols for the genetic and chemical validation of c-Fos and Dusp1 as a drug target in leukemia using in vitro and in vivo genetic and humanized mouse models. This method can be applied to any target for genetic validation and therapeutic development.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/58194