Radiochemical Syntheses, Volume 2 : Further Radiopharmaceuticals for Positron Emission Tomography and New Strategies for Their Production.
Title:
Radiochemical Syntheses, Volume 2 : Further Radiopharmaceuticals for Positron Emission Tomography and New Strategies for Their Production.
Author:
Scott, Peter J. H.
ISBN:
9781118834008
Personal Author:
Edition:
1st ed.
Physical Description:
1 online resource (288 pages)
Series:
Wiley Series on Radiochemical Syntheses
Contents:
Title Page -- Copyright Page -- Contents -- Radiochemical Syntheses -- Contributors -- Editorial Preface -- Abbreviations -- PART I FLUORINE-18 LABELED RADIOPHARMACEUTICALS -- Chapter 1 Synthesis of (−)-[18F]Flubatine ([18F]FLBT) -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 QUALITY CONTROL PROCEDURES -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Chapter 2 Synthesis of [18F]-(−)Fluoroethoxy Benzovesamicol ([18F]FEOBV) -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 QC PROCEDURES -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Chapter 3 Synthesis of [18F]Fluoromethylcholine ([18F]FCH) via [18F]Fluoromethyl Tosylate -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 QUALITY CONTROL -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Chapter 4 Radiosynthesis of [18F]Flotegatide ([18F]RGD-K5) -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 QUALITY CONTROL PROCEDURES -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Chapter 5 Synthesis of 3-[18F]Fluoro-5-(2-Pyridinylethynyl)Benzonitrile ([18F]FPEB) -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 QUALITY CONTROL PROCEDURES -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACT NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Chapter 6 Radiosynthesis of 2'-Deoxy-2'-[18F]Fluoro-5-Methyl- 1-β-d-Arabinofuranosyluracil ([18F]FMAU) -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 QC PROCEDURES -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- PART II CARBON-11 LABELED RADIOPHARMACEUTICALS -- Chapter 7 Synthesis of N-[11C]Methyl-4-Piperidinyl Propionate ([11C]PMP) -- 1 INTRODUCTION.
2 SYNTHESIS PROCEDURES -- 3 QUALITY CONTROL PROCEDURES -- WASTE DISPOSAL INFORMATION -- REFERENCES AND NOTES -- Chapter 8 Synthesis of 1-(2,4-Dichlorophenyl)-4-Cyano-5-(4-[11C]methoxyphenyl)-N-(Piperidin-1-yl)-1H-Pyrazole-3-Carboxamide ([11C]OMAR) -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 QC PROCEDURES -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Chapter 9 Synthesis of Carbon-11 Labeled (+)-4-Propyl-3,4,4a,5,6, 10b-Hexahydro-2H-Naphtho[1,2-B][1,4]Oxazin-9-Ol ([11C]-(+)-PHNO) -- 1 INTRODUCTION -- 2 SYNTHETIC PROCEDURES -- 3 QUALITY CONTROL PROCEDURES -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Chapter 10 Synthesis of (R)-[N-Methyl-11C]PK11195 -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 QUALITY CONTROL PROCEDURES -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- PART III OTHER RADIOPHARMACEUTICALS -- Chapter 11 Synthesis of Oxygen-15 Water ([15O]H2O) -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 QC PROCEDURES -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- PART IV NEW METHODS FOR THE SYNTHESIS AND QUALITY CONTROL OF RADIOPHARMACEUTICALS -- Chapter 12 Direct, Nucleophilic Radiosynthesis of [18F]Trifluoroethyl Tosylate -- 1 INTRODUCTION -- 2 PROCEDURES -- 3 DISCUSSION -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- References and Notes -- Chapter 13 Synthesis of [18F]N-Methyl Lansoprazole via Generation of a [18F]Trifluoromethyl Group -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 QUALITY CONTROL PROCEDURES -- 4 DISCUSSION -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES.
Chapter 14 [18F]Fluorination of (Mesityl)(Aryl)Iodonium Salts -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 QUALITY CONTROL PROCEDURES -- 4 DISCUSSION -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Chapter 15 Pd(IV)-Mediated Fluorination of Arenes with [18F]F- for PET Imaging -- 1 INTRODUCTION -- 2 HISTORY -- 3 PROCEDURES -- 4 DISCUSSION -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Chapter 16 Silicon Fluoride Acceptors (SiFAs) for Peptide and Protein Labeling with 18F -- 1 INTRODUCTION -- 2 PROCEDURES -- 3 DISCUSSION -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE -- REFERENCES AND NOTES -- Chapter 17 Solid Phase Synthesis of [18F]-2-Fluoro-2-Deoxy-d- Glucose: A Resin-Linker-Vector (RLV) Approach -- 1 INTRODUCTION -- 2 PROCEDURES -- 3 DISCUSSION -- 4 Experimental Supplement -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE -- REFERENCES AND NOTES -- Chapter 18 Production and Reaction of [11C]Carbon Disulfide for the Synthesis of [11C]Dithiocarbamates -- 1 INTRODUCTION -- 2 PROCEDURES -- 3 DISCUSSION -- ACKNOWLEDGMENTS -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Chapter 19 One-Pot, Direct Incorporation of [11CO2] into Carbamates -- 1 INTRODUCTION -- 2 PROCEDURES -- 3 QUALITY CONTROL PROCEDURES -- 4 DISCUSSION -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- NOTE -- REFERENCES -- Chapter 20 Radiosynthesis of [11C]Carboxamides via Reaction of [11C]CO2 Captured by a Cu(I)-Based Catalyst System with Boronic Acid Ester Precursors -- 1 INTRODUCTION -- 2 PROCEDURES -- 3 DISCUSSION -- ACKNOWLEDGMENTS -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE.
REFERENCES AND NOTES -- NOTES -- REFERENCES -- Chapter 21 Ethanol as a Solvent for Carbon-11 Radiochemistry -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 QC PROCEDURES -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Chapter 22 Synthesis and Applications of [11C]Hydrogen Cyanide -- 1 INTRODUCTION -- 2 SYNTHESIS PROCEDURES -- 3 REACTIONS WITH HYDROGEN CYANIDE -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Chapter 23 Determination of Radiochemical Purity and Radiochemical Identity of [13N]NH3 Using Thin Layer Chromatography -- 1 INTRODUCTION -- 2 PROCEDURES -- 3 DISCUSSION -- 4 SUMMARY -- WASTE DISPOSAL INFORMATION -- CHEMICAL ABSTRACTS NOMENCLATURE (REGISTRY NUMBER) -- REFERENCES AND NOTES -- Appendix Supplier Information -- Index -- EULA.
Abstract:
This book describes methods and procedures for preparing PET radiopharmaceuticals, and highlights new methods for conducting radiochemical reactions with carbon-11 (C11) and fluorine-18 (F18), which are two of the most commonly used radionuclides in positron emission tomography (PET) imaging. Provides reliable methods for radiochemical syntheses and reactions, including all essential information to duplicate the procedure Eliminates the time-consuming process of searching journal articles and extracting pertinent details from lengthy experimental sections or supporting information Focuses on an emerging and important area for pharmaceutical and medical applications Encompasses technical, regulatory, and application aspects Includes solid-phase radiochemistry, transition-metal catalyzed radiochemistry, microfluidics, click chemistry, green radiochemistry and new strategies for radiopharmaceutical quality control.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
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