Title and Frontmatter -- Preface -- Contents -- Contributors -- Volume 1 -- Introduction: Pediatric Gastroenterology: A Historical Perpective -- Section 1: Mouth and Esophagus -- 1. Congenital Anomalies -- 2. Disorders of the Oral Cavity -- 3. Disorders of Deglutition -- 4. Esophageal Motility -- 4.1 Normal Motility and Development of the Esophageal Neuroenteric System -- 4.2 Gastroesophageal Reflux -- 4.3 Other Neuromuscular Disorders -- 5. Esophagitis -- 6. Toxic and Traumatic Injury of the Esophagus -- Section 2: Stomach and Duodenum -- 7. Anatomy, Embryology and Congenital Anomalies -- 8. Nausea, Vomiting, and Pyloric Stenosis -- 9. Gastritis -- 9.1 Helicobacter pylori and Peptic Ulcer Disease -- 9.2 Acid-Peptic Disease -- 9.3 Other Causes of Gastritis -- 10. Tumors of the Pediatric Esophagus and Stomach -- 11. Gastric Motility -- 11.1 Normal Motility and Development of the Gastric Neuroenteric System -- 11.2 Motility Disorders -- Section 3: The Intestine -- 12. Anatomy and Embryology -- 13. Congenital Anomalies Including Hernias -- 14. Lymphatic Disorders -- 15. Absorption and Digestion -- 15.1 Normal Physiology of Intestinal Digestion and Absorption -- 15.2A Acute Diarrhea -- 15.2B Persistent Diarrhea -- 15.3 Congenital Disorders -- 15.3A Genetically Determined Disaccharidase Deficiency -- 15.3B Congenital Intestinal Transport Defects -- 15.3C Congenital Enteropathies -- 16. Immune Enteropathies -- 16.1 Celiac Disease -- 16.2 Food Allergic Enteropathy -- 16.3 Autoimmune Enteropathy and IPEX Syndrome -- 17. Surgical Disorders -- 17.1 Intestinal Obstructions -- 17.2 Appendicitis -- 17.3 Pediatric Ostomy -- 18. Benign Perianal Lesions -- 19. Microbial Interactions with Gut Epithelium -- 19.1A Probiotics -- 19.1B Prebiotics, Synbiotics, and Fermented Products -- 19.1C Antimicrobials -- 19.2 Infections -- 19.2A Bacterial Infections.

19.2B Viral Infections of the Intestinal Tract -- 19.2C Parasitic and Fungal Infections -- 19.2D Small Bowel Bacterial Overgrowth -- 20. Immune and Inflammatory Disorders -- 20.1 Inflammation -- 20.2 Gastrointestinal Manifestations of Primary Immunodeficiency Diseases -- 20.3 HIV and Other Secondary Immunodeficiencies -- 20.4 Necrotizing Enterocolitis -- 20.5 Chronic Inflammatory Bowel Disease -- 20.5A Crohn's Disease -- 20.5B Ulcerative and Indeterminate Colitis -- 20.5C Atypical Colitis and Other Inflammatory Diseases -- 20.5D Surgical Aspects of Inflammatory Bowel Disease in Children -- 20.6 Eosinophilic Gastrointestinal Diseases -- 20.7 Peritonitis and Intra-abdominal Abscesses -- 21. Malnutrition -- 22. Intestinal Failure -- 22.1 Short Bowel Syndrome -- 22.2 Parenteral Nutrition-Associated Liver Disease -- 22.3 Small Intestinal Transplantation -- 23. Intestinal Tumors -- 23.1 Intestinal Polyps and Polyposis -- 23.2 Other Neoplasms -- 24. Intestinal Motility -- 24.1 Normal Motility and Development of the Intestinal Neuroenteric System -- 24.2 Motility Disorders -- 24.2A Functional Constipation -- 24.2B Hirschsprung's Disease -- 24.2C Other Dysmotilities including Chronic Intestinal Pseudo-Obstruction Syndrome -- 24.3 Chronic Abdominal Pain Including Functional Abdominal Pain, Irritable Bowel Syndrome, and Abdominal Migraine -- 25. Gastrointestinal System in Systemic Endocrinopathies -- 26. Gastrointestinal Injury -- 26.1A Drug-Induced Bowel Injury -- 26.1B Radiation-Induced Bowel Injury -- Volume 2 -- Section 4: The Liver -- 27. Anatomy and Embryology -- 28. Physiology -- 28.1 Bile Formation and Cholestasis -- 28.2 Bilirubin Metabolism -- 28.3 Fibrogenesis and Cirrhosis -- 29. Approach to Neonatal Cholestasis -- 30. Disorders of the Biliary Tract -- 30.1 Disorders of the Intrahepatic Bile Ducts -- 30.2 Biliary Atresia -- 30.3 Other Disorders.

31. Infections -- 31.1A Hepatitis B Virus -- 31.1B Hepatitis C Virus -- 31.1C Other Viral Infections -- 31.2 Bacterial, Parasitic, and Other Infections -- 31.3 Immune Deficiency and the Liver -- 32. Autoimmune Liver Disease -- 33. Drug-Induced Hepatotoxicity in Children -- 34. Liver Tumors -- 35. Genetic and Metabolic Disorders -- 35.1 Disorders of Carbohydrate Metabolism -- 35.2 Disorders of Amino Acid Metabolism -- 35.3A Mitochondrial Function and Dysfunction -- 35.3B Inherited Abnormalities in Mitochondrial Fatty Acid Oxidation -- 35.4 A1-Antitrypsin Deficiency -- 35.5 Zellweger Syndrome and Other Disorders of Peroxisomal Metabolism -- 35.6 Lysosomal Acid Lipase Deficiencies: Wolman's Disease and Cholesteryl Ester Storage Disease -- 35.7 Wilson's Disease -- 35.8 Hemochromatosis -- 35.9 Disorders of Biliary Transport -- 35.10 Bile Acid Synthesis and Metabolism -- 36. Systemic Conditions Affecting the Liver -- 37. Acute Liver Failure -- 38. End-Stage Liver Disease -- 39. Liver Transplantation -- 40. Gallbladder Disease -- Section 5: The Pancreas -- 41. Pancreatic Function and Dysfunction -- 42. Congenital Anomalies of the Pancreas -- 43. Pancreatic Tumors -- 44. Pancreatitis -- 44.1 Acute and Chronic -- 44.2 Juvenile Tropical Pancreatitis -- 45. Exocrine Pancreatic Dysfunction -- 45.1 Cystic Fibrosis -- 45.2 Shwachman-Diamond Syndrome -- 45.3 Other Hereditary and Acquired Pancreatic Disorders -- 45.4 Pharmacological Therapy of Exocrine Pancreatic Insufficiency -- Section 6: Diagnosis of Gastrointestinal Disorders -- 46. Gastrointestinal Endoscopy -- 46.1 Patient Preparation and General Considerations -- 46.2A Upper Gastrointestinal Endoscopy -- 46.2B Upper Gastrointestinal Bleeding -- 46.3A Ileocolonoscopy and Enteroscopy -- 46.3B Lower Gastrointestinal Bleeding -- 46.4 Gastrointestinal Endosonography.

46.5 Endoscopic Retrograde Cholangiopancreatography -- 46.6 Interventional Endoscopy: Recent Innovations -- 47. Liver Biopsy Interpretation -- 48. Intestinal Biopsy -- 49. Gastrointestinal Manometry: Methodology and Indications -- 50. Esophageal pH and Impedance Measurement -- 51. Pancreatic Function Tests -- 52. Breath Analysis -- 53. Imaging -- 53.1 Plain Radiographs and Contrast Studies -- 53.2 Cross-Sectional Imaging: Ultrasonography, Computed Tomography, Magnetic Resonance Imaging -- 53.3 Interventional Radiology in the GI Tract in Children -- 53.4 Radionuclide Diagnosis -- Section 7: Psychosocial Aspects of Gastrointestinal Disorders -- 54. Gastrointestinal Features of Pediatric Illness Falsification -- 55. Management of Surgical Patients -- 56. Adherence to Medical Regimens -- Section 8: Principles of Clinical Investigation -- 57. Outcomes Research in Pediatric Gastroenterology -- 58. Methodology: Statistical Analysis, Test Interpretation, Basic Principles of Screening with Application for Clinical Study -- 59. Ethics and Regulatory Issues -- Index.