Diagnostic Approach to the Patient with Suspected Pulmonary Embolism -- Clinical Probability and D-Dimer Testing -- Imaging of Acute Pulmonary Embolism -- The Search for Deep Vein Thrombosis -- Risk Stratification of Pulmonary Embolism -- Cardiac Biomarkers in the Diagnostic Workup of Pulmonary Embolism -- Importance of a Patent Foramen Ovale -- Contemporary Diagnostic Algorithm for the Hemodynamically Stable Patient With Suspected Pulmonary Embolism -- Contemporary Diagnostic Algorithm for the Hemodynamically Unstable Patient With Suspected Massive Pulmonary Embolism -- Treatment and Secondary Prophylaxis of Venous Thromboembolism -- Heparin Anticoagulation -- Thrombolysis -- Management of the Patient With Fulminant Pulmonary Embolism Undergoing Cardiopulmonary Resuscitation -- Surgical Pulmonary Embolectomy -- Interventional Approaches to the Treatment of Acute Massive Pulmonary Embolism -- Vitamin K Antagonists and Novel Oral Anticoagulant -- Specific Aspects -- Hereditary and Acquired Thrombophilia -- Venous Thromboembolism and Cancer -- Pulmonary Embolism in Pregnancy -- Venous Thromboembolism in the Era of Air Travel -- Chronic Thromboembolic Pulmonary Hypertension.