front cover -- copyright -- front matter -- Preface to the First Edition -- Preface to the Second Edition -- Preface to the Third Edition -- Contributors -- table of contents -- Historical Aspects of Mucosal Immunology -- body -- Part I Mucosal Immune System -- Section A Mucosal Barrier: Development and Physiology of Mucosal Defense -- 1 Development and Physiology of Mucosal Defense: An Introduction -- 2 Mucosal Microbiota -- 3 Adhesion of Bacteria to Mucosal Surfaces -- 4 Mucus -- 5 Innate Humoral Defense Factors -- 6 Defensins and Other Antimicrobial Peptides and Proteins -- 7 Cellular and Molecular Basis for Antigen Transport Across Epithelial Barriers -- 8 Structure and Function of Intestinal Mucosal Epithelium -- 9 Mucosal Immunoglobulins -- 10 Organization and Expression of Genes Encoding IgA Heavy Chain, Polymeric Ig Receptor, and J Chain -- 11 Phylogeny and Comparative Physiology of IgA -- 12 Immunoglobulin Transport and the Polymeric Immunoglobulin Receptor -- 13 Fc Receptors -- 14 Biological Activities of IgA -- 15 Microbial Evasion of IgA Functions -- 16 Ontogeny of Mucosal Immunity and Aging -- 17 Phylogeny of the Gut-Associated Lymphoid Tissue (GALT) -- 18 The Role of Mucosal Microbiota in the Development, Maintenance, and Pathologies of the Mucosal Immune System -- Section B Inductive and Effector Tissues and Cells of the Mucosal Immune System -- 19 Inductive and Effector Tissues and Cells of the Mucosal Immune System: An Overview -- 20 Bronchus-Associated Lymphoid Tissues -- 21 Development and Function of Organized Gut-Associated Lymphoid Tissues -- 22 Human Gut-Associated Lymphoid Tissues -- 23 Nasal-Associated Lymphoid Tissue -- 24 Role of Epithelium in Mucosal Immunity -- 25 Role of Epithelial Cells in Mucosal Antigen Presentation -- 26 Antigen Handling and Presentation by Mucosal Dendritic Cells and Macrophages.

27 Oral Tolerance: Physiologic Basis and Clinical Applications -- 28 Th1/Th2/Th3 Cells for Regulation of Mucosal Immunity, Tolerance, and Inflammation -- 29 Cytotoxic T Cells of the Mucosal Immune System -- 30 Development, Function, and Specificity of Intestinal Intraepithelial Lymphocytes -- 31 IgA B Cell Development -- 32 The Human Mucosal B-Cell System -- 33 B-1 Cells and the Mucosal Immune System -- 34 Lymphocyte Homing: Chemokines and Adhesion Molecules in T cell and IgA Plasma Cell Localization in the Mucosal Immune System -- 35 Proinflammatory Cytokines and Signaling Pathways in Intestinal Innate Immune Cells -- 36 Mast Cells In Mucosal Defenses and Pathogenesis -- 37 Eosinophils -- 38 Neuropeptides for Mucosal Immunity -- Section C Mucosal Immunity and Infection -- 39 Mucosal Immunity and Infection: An Overview -- 40 Bacterial Interactions with Mucosal Epithelial Cells -- 41 Virus Infection of Epithelial Cells -- 42 Mucosal Immunity to Bacteria -- 43 Mucosal Immunity to Viruses -- 44 Mucosal Immune Response to Parasitic Infections -- 45 Parenteral Immunization Induces Mucosal Protection: A Challenge to the Mucosal Immunity Paradigm -- 46 Passive Immunization: Systemic and Mucosal -- Section D Mucosal Vaccines -- 47 Mucosal Vaccines: An Overview -- 48 Enteric Bacterial Vaccines: Salmonella, Shigella, Vibrio cholerae, Escherichia coli -- 49 Viral Gastroenteritis Vaccines -- 50 Respiratory Bacterial Vaccines -- 51 Respiratory Viral Vaccines -- 52 Mucosal Immunity and Vaccines Against Simian Immunodeficiency Virus and Human Immunodeficiency Virus -- 53 CpG Oligodeoxynucleotides for Mucosal Vaccines -- 54 Mucosal Adjuvants -- 55 Antigen Delivery Systems I: Nonliving Microparticles, Liposomes, and Immune Stimulating Complexes (ISCOMs).

56 Antigen Delivery Systems II: Development of Live Recombinant Attenuated Bacterial Antigen and DNA Vaccine Delivery Vector Vaccines -- 57 Recombinant Live Viral Vectors as Vaccines for Mucosal Immunity -- 58 Transgenic Plants for Mucosal Vaccines -- 59 Antigen Delivery Systems III: Use of Recombinant Plant Viruses -- 60 DNA Vaccines for Mucosal Immunity to Infectious Diseases -- 61 Mucosal Veterinary Vaccines: Comparative Vaccinology -- 62 Mucosal Vaccines for Dental Diseases -- Part II Mucosal Diseases -- Section E Immunodeficiency -- 63 Immunodeficiency and Mucosal Immunity: An Overview -- 64 Immunodeficiency and Mucosal Immunity -- 65 Undernutrition, Immunodeficiency, and Mucosal Infections -- 66 Mucosal Infection and Immune Responses to Simian Immunodeficiency Virus -- 67 Immunobiology of Mucosal HIV-1 Infection -- Section F Stomach, Liver, and Intestine -- 68 Mucosal Injury and Immunopathology: An Overview -- 69 Peptic Ulcers and Gastritis -- 70 Disease Induction and Prevention in Experimental Models of Inflammatory Bowel Disease -- 71 Ulcerative Colitis: Evolving Insights into Pathogenesis -- 72 Crohn's Disease: Current Pathogenetic Paradigms -- 73 Protein-Losing Enteropathies -- 74 Celiac Disease -- 75 Food Allergy: Immunophysiology -- 76 Allergic Diseases in the Gastrointestinal Tract -- 77 Gastrointestinal Lymphoma -- 78 Liver and Biliary Tract -- 79 Systemic Manifestations of Mucosal Diseases: Trafficking of Gut Immune Cells to Joints and Liver -- Section G Respiratory Tract -- 80 Mucosal and Other Mechanisms of Resistance in the Respiratory Tract: An Overview -- 81 Experimental Models of Airway Hyperresponsiveness -- 82 Asthma: Clinical Aspects and Mucosal Immunology -- 83 Clinical Aspects of Bronchial Reactivity and Cell-Virus Interaction -- 84 Immune Responses to Mycoplasma -- 85 Local Immune Responses in Tuberculosis.

Section H Oral Cavity, Upper Airway, and Head and Neck -- 86 Ocular Mucosal Immunity -- 87 Nasal Immunologic Reactivity, Rhinitis, and Polyps -- 88 Middle Ear and Eustachian Tube -- 89 Immunology of Diseases of the Oral Cavity -- 90 Immunobiology of the Tonsils and Adenoids -- Section I Genitourinary Tract and Mammary Gland -- 91 Immunology and Immunopathology of the Genitourinary Tract: An Overview -- 92 IgA Nephropathy and Related Diseases -- 93 Urinary Tract Infections and the Mucosal Immune System -- 94 Female Genital Tract Infections and Immunity in Animal Models -- 95 Mucosal Immunity in the Human Female Reproductive Tract -- 96 Human Male Genital Tract Immunity and Experimental Models -- 97 Endocrine Regulation of the Mucosal Immune System in the Female Reproductive Tract -- 98 Immunologically Mediated Male and Female Reproductive Failure -- 99 Mucosal Immunology of Sexually Transmitted Diseases -- 100 Maternal Genital Tract Infection and the Neonate -- 101 Immunity at the Maternal-Fetal Interface -- 102 Amniotic Fluid and the Fetal Mucosal Immune System -- 103 Immunoglobulins and Immunocytes in the Mammary Gland and Its Secretions -- 104 Human Milk: Its Components and Their Immunobiologic Functions -- back matter -- Appendix I Collection and Processing of Human Mucosal Secretions -- Appendix II Collection and Processing of External Secretions and Tissues of Mouse Origin -- Appendix III Collection, Handling, and Analysis of Specimens for Studies of Mucosal Immunity in Large Animals -- Abbreviations -- index -- Color Plates.