Substance P in the nervous system -- Contents -- Introduction -- Chemical neurotransmission-yesterday and today -- Role of substance P as a sensory transmitter in spinal cord and sympathetic ganglia -- Discussion -- Substance P in peripheral sensory processes -- Discussion -- Localization of substance P in neuronal pathways -- Discussion -- Distribution of substance P in brain and periphery and its posible role as a co-transmitter -- Discussion -- Regulation of substance P expression and metabolism in vivo and in vitro -- Discussion -- GENERAL DISCUSSION -- Coexistence of transmitters -- Substance P in nerve tissue in the gut -- Discussion -- Biosynthesis, axonal transport and turnover of neuronal substance P -- Discussion -- Enzymic inactivation of substance P in the central nervous system -- Discussion -- Substance P receptors in the nervous system and possible receptor subtypes -- Discussion -- Relation of substance P to pain transmission: neurophysiological evidence -- Discussion -- Substance P in nociceptive sensory neurons -- Discussion -- If substance P fails to fulfil the criteria as a neurotransmitter in somatosensory afferents, what might be its function? -- Discussion -- Modulation of cholinergic transmission by substance P -- Discussion -- The striatonigral substance P pathway and dopaminergic mechanisms -- Discussion -- Relation of substance P to stress and catecholamine metabolism -- Discussion -- Behavioural effects of substance P through dopaminergic pathways in the brain -- Discussion -- FINAL GENERAL DISCUSSION -- Substance P antagonists -- tumour cell lines and substance P -- substance P and other tachykinins -- substance P and clinical pain syndromes -- substance P and neuronal systems -- Index of contributors -- Subject index.