Protein Degradation in Health and Disease -- Contents -- Introduction: the classification of proteinases -- Discussion -- Lysosomal cysteine proteinases -- Discussion -- Cathepsin D: the lysosomal aspartic proteinase -- Discussion -- Human leucocyte elastase and cathepsin G: structural and functional characteristics -- Discussion -- Human collagenases: comparative and immunolocalization studies -- Discussion -- Proteinases in connective tissue breakdown -- Discussion -- Cellular mechanisms of proteinase release from inflammatory cells and the degradation of extracellular proteins -- Discussion -- Inactivation of cytosol enzymes by a liver membrane protein -- Discussion -- Lysosomes and protein degradation -- Discussion -- Insights into mechanisms of intracellular protein turnover from studies on pinocytosis -- Discussion -- Turnover and degradation of mitochondria and their proteins -- Discussion -- Protein degradation in cells in culture -- Discussion -- Regulation of protein breakdown in hepatocyte monolayers -- Discussion -- A possible role for neutral proteolysis in the degradation of intracellular proteins -- Discussion -- Studies of the ATP dependence of protein degradation in cells and cell extracts -- Discussion -- Coordination of protein synthesis and degradation -- Discussion -- General discussion Sites of protein degradation -- Application of liver perfusion as an in vitro model in studies of intracellular protein degradation -- Discussion -- Protein degradation and the regulation of protein balance in muscle -- Discussion -- Protein degradation in metabolic and nutritional disorders -- Discussion -- Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia): biochemical, pathophysiological and therapeutic aspects -- Discussion -- Neutral proteinases of leucocytes and the inflammatory process.

Discussion -- Final general discussion -- Concluding remarks -- Index of contributors -- Subject index.