MOLECULAR RECOGNITION: BIOTECHNOLOGY, CHEMICAL ENGINEERING AND MATERIALS APPLICATIONS -- MOLECULAR RECOGNITION: BIOTECHNOLOGY, CHEMICAL ENGINEERING AND MATERIALS APPLICATIONS -- CONTENTS -- PREFACE -- Chapter 1 MOLECULAR RECOGNITION OF CARBOXYLIC ACIDS AND CARBOXYLATE ANIONS BY SYNTHETIC RECEPTOR -- ABSTRACT -- 1. INTRODUCTION -- 2. SYNTHETIC RECEPTOR MOLECULES FOR THE SENSING OF CARBOXYLATE ANIONS AND CARBOXYLIC ACIDS -- 2.1. MACROCYCLIC POLYAMINES -- 2.2. PROTONATED HETEROCYCLES -- 2.3. RECEPTORS WITH GUANIDINE AND AMIDINE FUNCTIONS -- 2.4. RECEPTORS CONTAINING UREA AND THIOUREA MOIETIES -- 2.5. RECEPTORS CONTAINING AMIDE GROUP -- 2.6. RECEPTOR WITH AMIDOPYRIDINE FRAGMENT -- 2.7. METAL-BASED RECEPTORS -- 2.8. RECEPTORS BASED ON CYCLODEXTRINS AND CALIXARENES -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 2 NEXT GENERATION MOLECULAR IMPRINTED POLYMERS: EXAMPLES OF LIQUID CRYSTALLINE MATERIALS AND HYDROGELS FOR PROTEIN RECOGNITION -- ABSTRACT -- INTRODUCTION -- 1. LIQUID CRYSTAL MIPS -- I.1. CHIRAL RECOGNITION IN LC-MIPS -- I.2. CATALYTIC LC-MIPS -- I.3. APPLICATION TO THE RECOGNITION OF PESTICIDES -- II. HYDROGEL MIPS FOR PROTEIN RECOGNITION -- II.1. RECENT ACCOMPLISHMENTS -- II.2. PATTERNING OF MIPS FOR MICRO- AND NANOSYSTEMS APPLICATIONS -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 3 MOLECULAR RECOGNITION AND CRYSTAL GROWTH -- ABSTRACT -- 1. INTRODUCTION: SUPRAMOLECULAR CHEMISTRY AND MOLECULAR RECOGNITION -- 2. MOLECULAR RECOGNITION BY BIOLOGICAL RECEPTORS -- 2.1. DRUG ACTION MECHANISM -- 2.2. SWEETNESS PERCEPTION -- 3. HYDROGEN BONDING IN MOLECULAR RECOGNITION -- 3.1. GENERAL FEATURES OF HYDROGEN BONDING -- 3.2. INFRARED SPECTROSCOPY AND HYDROGEN BONDING -- 4. CO-CRYSTALS -- 5. POLYMORPHISM -- 6. MOLECULAR RECOGNITION IN SOLUTION AND CRYSTAL STRUCTURE.

7. CONFORMATIONAL RECOGNITION IN SOLUTION AND CRYSTAL STRUCTURE -- 8. MOLECULAR RECOGNITION AT INTERFACES -- 8.1. CRYSTAL GROWTH IN THE PRESENCE OF TAYLOR-MADE ADDITIVES -- 8.2. EFFECT OF THE SOLVENT ON THE CRYSTALLINE HABIT -- 8.3. CONFORMATIONAL MIMICRY -- 8.4. SEEDING CRYSTALLIZATION -- CONCLUDING REMARKS -- REFERENCES -- Chapter 4 SPECTROSCOPIC AND MICROSCOPIC EXAMINATION OF CHIRAL RECOGNITION AT THE MOLECULAR LEVEL -- ABSTRACT -- INTRODUCTION -- INFRARED -- RAMAN -- STM -- AFM -- CHIRAL SURFACES AND THEIR INVESTIGATION BY STM AND AFM -- CHIRAL RECOGNITION AND IR AND SERS -- CHIRAL SURFACES AND OTHERS METHODS -- ACKNOWLEDGMENT -- CONCLUSION -- REFERENCES -- Chapter 5 MOLECULAR IMPRINTING: STATE OF THE ART AND APPLICATIONS -- 1.1. GENERAL INTRODUCTION -- 1.2. MOLECULAR IMPRINTING UNDERLYING PRINCIPLE -- 1.3. IMPRINTING MECHANISMS -- 1.3.1. COVALENT IMPRINTING -- 1.3.2. NON-COVALENT IMPRINTING -- 1.4. FACTORS AFFECTING IMPRINTING PROCESS -- 1.4.1. MONOMER SELECTION -- 1.4.2.TEMPLATE, FUNCTIONAL MONOMER AND CROSS-LINKER MOLAR RATIO -- I.4.3. ROLE OF CROSS-LINKERS -- 1.5.4. TEMPERATURE EFFECT -- 1.5.5. RECOGNITION MEDIA AND PROGEN -- 1.4.6. PH OF THE IMPRINTING SOLUTION -- 1.4.7. PH OF THE REBINDING MIXTURE -- 1.5. IMPRINTED MATERIALS ANALYTICAL CHARACTERISTICS AND RECOGNITION AND ANALYTICAL CHALLENGES -- 1.5.1. REBINDING EFFICIENCY AND TEMPLATE RECOVERY -- 1.5.2. MOLECULAR SELECTIVITY OF THE IMPRINTED MATERIALS -- 1.5.3. REPEATABILITY OF REBINDING PROCESS -- 1.6. CLASSIFICATION OF THE IMPRINTED MATERIALS ACCORDING TO THE TYPE OF MONMER -- 1.6.1. IMPRINTING IN ORGANIC MATERIALS -- 1.6.2. IMPRINTING IN INORGANIC MATERIALS -- 1.7. COMPUTATIONAL APPROACHES TO MIPS -- 1.8. THE POTENTIAL APPLICATIONS OF MOLECULARLY IMPRINTED MATERIALS -- 1.8.1. SEPARATION AND EXTRACTION OF MOLECULES -- 1.8.2. PREPARATION OF ANTIBODY ANALOGUES.

1.8.3. MOLECULARLY IMPRINTED CATALYSTS -- 1.8.4. MOLECULARLY IMPRINTED MATERIALS FOR SENSORY APPLICATIONS -- 1.8.5. MOLECULARLY IMPRINTED MEMBRANES -- REFERENCES -- Chapter 6 RECENT ADVANCES IN DNA-LIGAND MOLECULAR RECOGNITION AND ALLOSTERIC INTERACTIONS -- ABSTRACT -- 1. INTRODUCTION -- 2. MONODENTATE INTERACTIONS AND BIDENTATE INTERACTIONS -- 3. DNA-SMALL LIGAND MOLECULAR RECOGNITION IN THE MINOR GROOVE -- 4. DNA-LIGAND ALLOSTERIC INTERACTIONS -- 5. DETERMINATION OF DNA-PEPTIDE BINDING COOPERATIVITY BY THE HILL PLOT -- 6. DNA-PEPTIDE ALLOSTERIC INTERACTION NETWORKS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 7 MOLECULAR RECOGNITION OF ODORANT-BINDING PROTEINS IN INSECT OLFACTION -- ABSTRACT -- INTRODUCTION -- THREE DIMENSIONAL STRUCTURES AND BINDING SITES OF OBPS -- PH-DEPENDENT CONFORMATIONAL CHANGE AND LIGAND RELEASE IN OBPS -- BINDING PREFERENCE AND INITIAL RECOGNITION OF OBPS -- OBP/ODORANT COMPLEXES MAY ACT AS SIGNAL TRIGGERS -- CONCLUSION -- REFERENCES -- Chapter 8 THE PROTEOMIC CODE: A MOLECULAR RECOGNITION CODE FOR PROTEINS -- ABSTRACT -- ABBREVIATIONS -- INTRODUCTION -- THE HISTORY OF THE PROTEOMIC CODE -- PEOPLE FROM THE PAST -- FIRST GENERATION MODELS FOR THE PROTEOMIC CODE -- MEKLER -- BIRO -- BLALOCK-SMITH -- ROOT-BERNSTEIN -- SIEMION -- MILLER -- THE PROTEOMIC CODE AND THE 3D STRUCTURE OF PROTEINS -- EXPERIMENTAL EVIDENCE -- REVERSE BUT NOT COMPLEMENTARY SEQUENCES -- CONTROVERSIES REGARDING THE ORIGINAL PROTEOMIC CODES -- DEVELOPMENT OF THE SECOND GENERATION PROTEOMIC CODE -- CONSTRUCTION OF A COMMON PERIODIC TABLE OF CODONS AND AMINO ACIDS -- THE PHYSICO-CHEMICAL COMPATIBILITY OF AMINO ACIDS IN THE PROTEOMIC CODE -- SEQX -- AVAILABILITY AND REQUIREMENTS -- AMINO ACID SIZE, CHARGE, HYDROPATHY INDICES AND MATRICES FOR PROTEIN STRUCTURE ANALYSIS -- ANFINSEN'S THERMODYNAMIC PRINCIPLE AND THE PROTEOMIC CODE.

PROTEIN STRUCTURE AND THE FUNCTIONAL ASYMMETRY OF THE CODONS -- COMPARISON OF THE PROTEIN AND MRNA SECONDARY STRUCTURES -- COMPLEMENTARY CODES VS AMINO ACID CO-LOCATIONS -- AVAILABILITY -- THEORY OF NUCLEIC ACID (CHAPERONS) ASSISTED PROTEIN FOLDING -- DEFINITION OF THE 2ND GENERATION PROTEOMIC CODE -- SYSTEM AND METHOD TO OBTAIN OLIGO-PEPTIDES WITH SPECIFIC HIGH AFFINITY TO QUERY PROTEINS -- EXAMPLE 1 -- EXAMPLE 2. EXAMPLE FOR DESIGNING AND CHARACTERIZATION OF A SPECIFIC PROTEIN-PROTEIN INTERACTION -- DEFINITIONS -- THE EXPERIMENT -- CONCLUSION -- THE PROMISES OF THE SECOND GENERATION PROTEOMIC CODE -- Industrial Applications -- Scientific Potential -- THE VISION OF A PROTEOME-SENSOR CHIP -- THE VISION OF A NEW PHYSIOLOGY -- THE VISION OF NEW PROTEIN-BASED THERAPEUTIC APPROACHES -- SOFTWARE -- PATENTS -- ROOT-BERNSTEIN -- COMPETING INTERESTS -- ACKNOWLEDGMENTS -- REFERENCES -- REFERENCES TO TABLE I -- Chapter 9 'ON/OFF'-SWITCHED MOLECULAR RECOGNITION BY A SMART AMINOPURINE-IMPRINTED POLYMER -- ABSTRACT -- 1. INTRODUCTION -- 2. EXPERIMENTAL SECTION -- 2.1. PREPARATION OF IMPRINTED POLYMERS -- 2.2. TEMPERATURE-PROGRAMMED DESORPTION -- 2.3. EVALUATION OF PHASE TRANSITION -- 2.4. SORPTION TEST -- 2.5. DYNAMIC ADSORBING-DESORBING CYCLIC VOLTAMMETRY -- 3. RESULTS AND DISCUSSION -- 3.1. FTIR AND SEM ANALYSIS OF MOLECULAR IMPRINTING -- 3.2. SPECIFIC INTERACTION BETWEEN IMPRINTED POLYMERS AND SUBSTRATE -- 3.3. PHASE TRANSITION BEHAVIOR -- 3.4. SWITCHED MOLECULAR RECOGNITION -- 3.5. TRACK OF KINETICS -- 3.6. DYNAMIC BINDING BEHAVIOR -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- INDEX -- Blank Page.