Front Matter -- Reviewers -- Foreword -- Preface -- Acknowledgments -- Contents -- Abstract -- Summary -- Part I: The Imperatives -- 1 Introduction and Overview -- 2 Imperative: Managing Rapidly Increasing Complexity -- 3 Imperative: Achieving Greater Value in Health Care -- 4 Imperative: Capturing Opportunities from Technology, Industry, and Policy -- Part II: The Vision -- 5 A Continuously Learning Health Care System -- Part III: The Path -- 6 Generating and Applying Knowledge in Real Time -- 7 Engaging Patients, Families, and Communities -- 8 Achieving and Rewarding High-Value Care -- 9 Creating a New Culture of Care -- 10 Actions for Continuous Learning, Best Care, and Lower Costs -- Appendix A: Glossary -- Appendix B: A CEO Checklist for High-Value Health Care -- Appendix C: ACA Provisions with Implications for a Learning Health Care System -- Appendix D: Biosketches of Committee Members and Staff.