FrontMatter -- Reviewers -- Institute of Medicine Roundtable on Value & Science-Driven Health Care Charter and Vision Statement -- Foreword -- Preface -- Contents -- Abbreviations and Acronyms -- Synopsis and Highlights -- 1 Introduction -- 2 Visioning Perspectives on the Digital Health Utility -- 3 Technical Issues for the Digital Health Infrastructure -- 4 Engaging Patient and Population Needs -- 5 Weaving a Strong Trust Fabric -- 6 Stewardship and Governance in the Learning Health System -- 7 Perspectives on Innovation -- 8 Fostering the Global Dimension of the Health Data Trust -- 9 Growing the Digital Health Infrastructure -- 10 Accelerating Progress -- Appendix A: The Learning Health System and the Digital Health Utility -- Appendix B: Case Studies for the Digital Health Infrastructure -- Appendix C: Example Stakeholder Responsibilities and Opportunities -- Appendix D: Summary Overview of Meaningful Use Objectives -- Appendix E: PCAST Report Recommendations -- Appendix F: Workshop Agendas -- Appendix G: Workshop Participants -- Other Publications in The Learning Health System Series.