FrontMatter -- Reviewers -- Preface -- Acknowledgments -- Contents -- Executive Summary -- Overview of Conclusions and Recommendations -- 1 Introduction -- 2 The Science of Developing Cancer Therapy -- 3 Operations, Oversight, and Funding of Cancer Clinical Trials -- 4 Physician and Patient Participation in Cancer Clinical Trials -- Appendix A: Previous and Ongoing Analyses Undertaken by NCI -- Appendix B: Committee Member and Staff Biographies -- Acronyms -- Glossary.