CRISPR-Mediated Reorganization of Chromatin Loop Structure
Title:
CRISPR-Mediated Reorganization of Chromatin Loop Structure
Author:
Morgan, Stefanie L.
Personal Author:
Publication Information:
Cambridge, MA MyJoVE Corp 2016
Physical Description:
online resource (560 seconds)
Series:
Genetics
General Note:
Title from resource description page
Abstract:
Chromatin looping plays a significant role in gene regulation; however, there have been no technological advances that allow for selective and reversible modification of chromatin loops. Here we describe a powerful system for chromatin loop re-organization using CRISPR-dCas9 (CLOuD9), demonstrated to selectively and reversibly modulate gene expression at targeted loci.
Reading Level:
For undergraduate, graduate, and professional students
Subject Term:
Electronic Access:
https://www.jove.com/t/57457