9781847355645 _Front Cover.pdf -- 9781847355645 _Content.pdf -- Update on Polymers for Ocular Drug Delivery -- Dedication and Acknowledgements -- Contents -- Preface -- 1 Introduction: Overview of Ocular Drug Delivery -- 1.1 Drug Delivery and Polymer Science -- 1.2 Ocular Drug Delivery -- 1.2.1 Anatomy and Physiology of the Eye -- 1.2.2 Pharmacokinetics of Drugs Delivered through the Ocular Route -- References -- 2 Conventional Ocular Drug Delivery -- 2.1 Introduction -- 2.2 Eye Drops -- 2.2.1 Aqueous Solutions -- 2.2.2 Ophthalmic Suspensions -- 2.3 Semisolids -- 2.4 Summary and Conclusion -- References -- 3 Hydrogels and Viscosity Modifiers -- 3.1 Introduction -- 3.2 Hydrogels -- 3.2.1 Sodium Hyaluronate -- 3.2.2 Cellulose Derivatives -- 3.2.3 Polyvinyl Alcohol -- 3.2.4 Carbomers -- 3.2.5 Miscellaneous Polymers -- 3.3 Viscosity Enhancing Agents -- 3.3.1 Cellulose Derivatives -- 3.3.2 Acrylates -- 3.3.3 Hyaluronic Acid -- 3.3.4 Chitosan -- 3.3.5 Thiomers -- 3.3.6 Others -- 3.4 Summary and Conclusion -- References -- 4 Ocular Inserts -- 4.1 Introduction -- 4.2 Ocular Inserts as Drug Delivery Systems -- 4.2.1 Soluble Ocular Drug Inserts -- 4.2.1.1 Inserts Based on Natural Polymers -- 4.2.1.2 Inserts Based on Synthetic and Semisynthetic Polymers -- 4.2.1.3 Inserts Utilising Particular Approaches -- 4.2.1.3.1 The Mucoadhesive Approach -- 4.2.1.3.2 The Prodrug Approach -- 4.2.1.3.3 The Drug Carrier Approach -- 4.2.2 Insoluble Ocular Drug Inserts -- 4.2.2.1 Diffusional Inserts -- 4.2.2.2 Osmotic Inserts -- 4.2.2.3 Contact Lenses -- 4.2.3 Bioerodible Inserts -- 4.3 Summary and Conclusion -- References -- 5 Particulate Drug Delivery -- 5.1 Introduction -- 5.2 Nanoparticles and Polymers used in their Preparation -- 5.2.1 Acrylates -- 5.2.1.1 Polyalkylcyanoacrylate -- 5.2.1.2 Acrylate Derivatives -- 5.2.2 Polyester-based Nanoparticles.

5.2.2.1 Poly-ε-caprolactone -- 5.2.2.2 Poly(D,L-lactic acid) and Poly(D,L-lactide-co-glycolide) -- 5.2.3 Natural Polymer Based Nanoparticles -- 5.2.3.1 Protein Nanoparticles -- 5.2.3.2 Polysaccharide Based Nanoparticles -- 5.2.3.3 Lipid Based Nanoparticles -- 5.2.4 Polymeric Coating to Nanoparticles -- 5.3 Microparticles and Polymers used in their Preparation -- 5.3.1 Ocular Delivery of Drug Loaded Microparticulates -- 5.3.2 Polymers used in the Preparation of Microparticulates -- 5.3.2.1 Acrylates -- 5.3.2.2 Poly(D,L-lactic acid) and Poly (D,L-lactide-co-glycolide) -- 5.3.2.3 Natural Polymers -- 5.3.2.4 Lipids -- 5.4 Summary and Conclusion -- 5.2.4.1 Polysaccharide Coating -- 5.2.4.2 Polyacrylic Coating -- 5.2.4.3 Polyethylene Glycol Coating -- References -- 6 In Situ Gelling Polymers in Ocular Drug Delivery -- 6.1 Introduction -- 6.2 In Situ Gelling Hydrogels -- 6.2.1 Temperature-induced In Situ Gelling Polymeric Carriers -- 6.2.1.1 Poloxamers (Pluronic) and their Analogues -- 6.2.1.2 Xyloglucan -- 6.2.1.3 Cellulose Derivatives -- 6.2.2 pH-induced In Situ Gelling Polymeric Carriers -- 6.2.2.1 Carbomers -- 6.2.2.2 Pseudolatexes -- 6.2.3 Osmotically Induced In Situ Gelling Polymeric Carriers -- 6.2.3.1 Gellan Gum (Gelrite) -- 6.2.3.2 Alginates -- 6.2.4 Dual Mechanism based In Situ Gelling Polymeric Carriers -- 6.2.4.1 Carrageenans and Chitosan -- 6.3 Summary and Conclusion -- References -- 7 Intraocular Implants -- 7.1 Introduction -- 7.2 Polymers used for Intraocular Drug Delivery Implants -- 7.2.1 Nonbiodegradable Solid Implants -- 7.2.1.1 Polyvinyl Alcohol - Ethylene Vinyl Acetate -- 7.2.1.2 Polysulfone Capillary Fibre -- 7.2.2 Biodegradable Solid Implants -- 7.2.2.1 Polylactic Acid, Polyglycolic Acid and Poly(D,L-lactide-co-glycolide) -- 7.2.2.2 Polycaprolactones -- 7.2.2.3 Polyanhydrides -- 7.2.3 Viscous and Injectable Polymers.

7.2.3.1 Polyorthoesters -- 7.3 Summary and Conclusion -- 7.4 Future Directions for Ophthalmic Research -- References -- Abbreviations -- Index -- 9781847355645 _Back Cover.pdf.