Bioinformatics : A Primer.
Title:
Bioinformatics : A Primer.
Author:
Narayanan, P.
ISBN:
9788122426465
Personal Author:
Edition:
1st ed.
Physical Description:
1 online resource (261 pages)
Contents:
Cover -- Preface -- Acknowledgement -- Contents -- Chapter 1 Bioinformatics: Introduction -- 1.1 "Bioinformatics" -- 1.2 The Objectives of Bioinformatics -- Chapter 2 Atoms and Molecules -- 2.1 Atomic Structure -- 2.2 Molecules -- Chapter 3 Features of Nucleic Acids -- 3.1 Constituents of Nucleic Acids -- 3.2 Polynucleotides -- 3.3 The Genome Projects -- Chapter 4 Features of Proteins -- 4.1 Amino Acids -- 4.2 Proteins -- 4.3 Forces Stabilizing the Molecular Structure -- Chapter 5 Physicochemical Characterization of Biomolecules -- 5.1 Hydrodynamical Methods -- 5.2 Chromatographic Methods -- 5.3 Electrophoretic Methods -- 5.4 Blotting Techniques -- Chapter 6 Primary Structure (Sequence) Determination of Biomolecules -- 6.1 Primary Structure Determination of Nucleic Acids -- 6.2 Primary Structure Determination of Proteins -- Chapter 7 Spatial Structure Determination of Biomolecules -- 7.1 X-Ray Diffraction Methods -- 7.2 Nuclear Magnetic Resonance (NMR) Spectroscopy -- 7.3 Imaging Methods -- Chapter 8 Protein-Ligand Interactions -- 8.1 Protein-Nucleic Acid Interactions -- 8.2 Protein-Protein Interactions -- 8.3 Protein-Carbohydrate Interactions -- 8.4 Protein-Lipid Interactions -- Chapter 9 The Protein-folding Problem -- 9.1 Genomics Analysis -- 9.2 Proteomic Analysis -- Chapter 10. Computational Methods in Structure Prediction -- 10.1 Protein Folding Rules -- 10.2 Structure Prediction of Fibrous Proteins -- 10.3 Structure Prediction of Globular Proteins -- 10.4 Application of Structure Prediction Programs -- Chapter 11 Database Search -- 11.1 Primary Structure (Sequence) -- 11.2 Databases -- 11.3 Genome Datbase Search -- 11.4 Protein Database Search -- Chapter 12 Data Mining, Analysis and Modeling -- 12.1 Sequence Alignment Analysis -- 12.2 Pair-Wise Sequence Alignment -- 12.3 Multiple Sequence Alignment (MSA) -- 12.4 Phylogenetic Analysis.
12.5 Secondary Structure Analysis -- 12.6 Motifs, Domains and Profiles -- 12.7 Pattern Recognition -- 12.8 Protein Classification and Modeling -- Chapter 13 Medico- and Pharmacoinformatics -- 13.1 Disease Gene Identification -- 13.2 Genetic Variations and Genetic Diseases -- 13.3 Genetic Testing and Therapy -- Chapter 14 Molecular Engineering -- 14.1 Genomics and Proteomics Analysis -- 14.2 Rational Design -- 14.3 Validation -- Glossary -- Index.
Abstract:
About the Book: Bioinformatics is the bridge between experimental data in diverse biologically related disciplines and extrapolation of information, by computational analysis, about how the systems and processes function. The central aims are: (i) elucidation (by experimental methods) of structural features of the biological entities (proteins, nucleic acids, etc.), (ii) application of computational tools and approaches to study of information content, organization, and processing in biological systems, (iii) application of medical and health data at the molecular level (biomedinformatics), annotation of structural and chemical characteristics in molecular and drug design (cheminformatics). Thus, it requires trans-disciplinary collaboration between biophysicists, drug chemists, molecular biologists, biomedical and computer-aided modeling experts. Acquisition of high-throughput biological data (e.g. from the genomic projects) at fast rate has ushered in computer-intensive data analysis (in silico analysis). But, considerable "algorithmic" complexity of biological systems requires a vast of amount of detailed information (experimental and computational) at the cellular and molecular levels for their complete description. Therefore, there is a need for books in this subject with due emphasis on both experimental as well as computational aspects. With these broad objectives in mind, the material contents of this book are organized under-molecular biophysics, experimental methods of structure elucidation, database search, data mining and analysis, computational methods of structure prediction, and rational molecular/drug design (molecular engineering) and validation, with easy interface between these areas and various chapters. Ample tables and figures are intended to facilitate the readers an insight to the structure-function features at the
molecular level. Exercise modules and bibliography for each chapter, and glossary are aimed at providing the reader wider perception and insight to the subject matter, and scientific and technical terms. Index is provided to help an easy access to the words and topics to the subject matter. Contents: Bioinformatics : Introduction. Section I: Biomolecular Structures (Molecular Biophysics) Atoms and Molecules Features of Nucleic Acids Features of Proteins Section II: Experimental Methods of Structure Elucidation (Bioinformatics-I) Physicochemical Characterization of Biomolecules Primary Structure (Sequence) Determination of Biomolecules Spatial Structure Determination of Biomolecules Protein-Ligand Interactions Section III: Towards Structure Prediction (Bioinformatics-II) The Protein-folding Problem Computational Methods in Structure Prediction Section IV: Database Search, Analysis and Modeling (Bioinformatics-III) Database Search Data Mining, Analysis and Modeling Medico and Pharmacoinformatics Molecular Engineering.
Local Note:
Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2017. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.
Genre:
Electronic Access:
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