POSSIBLE LONG-TERM HEALTH EFFECTS OF SHORT-TERM EXPOSURE TO CHEMICAL AGENTS -- Copyright -- ACKNOWLEDGMENTS -- PREFACE -- EXECUTIVE SUMMARY -- CHOLINESTERASE REACTIVATORS -- PSYCHOCHEMICALS -- IRRITANTS AND VESICANTS -- MUSTARD GAS (H) -- o-CHLOROBENZYLIDENE MALONONITRILE (CS) -- CHLOROACETOPHENONE (CN) -- DIBENZ[b,f][1,4]OXAZEPINE (CR) -- CHLOROPICRIN (PS) -- BROMBENZYL CYANIDE (CA), DIPHENYLAMINOCHLORARSINE (DM), and 1-METHOXY-1,3,5-CYCLOHEPTATRIENE (CHT) -- NONANOYL MORPHOLIDE -- 123 IRRITANT CHEMICALS -- OVERVIEW -- Contents -- 1 INTRODUCTION -- REFERENCES -- 2 CHOLINESTERASE REACTIVATORS -- BACKGROUND -- REFERENCES -- REVIEW OF AVAILABLE INFORMATION ON 2-PAM, P2S, TMB-4, AND TOXOGONIN -- CHARACTERISTICS -- BIOCHEMISTRY -- MECHANISMS OF ACTION -- PHARMACOKINETICS -- ADVERSE EFFECTS -- GASTROINTESTINAL EFFECTS -- CARDIOVASCULAR EFFECTS -- NEUROPHARMACOLOGY -- Effects of Oximes on AChE Activity -- Receptor Interactions -- Ganglionic Blocking Action -- Presynaptic Effects of Oximes -- MUTAGENIC, REPRODUCTIVE, AND CARCINOGENIC EFFECTS -- THERAPEUTIC USE -- DELAYED AND LONG-TERM EFFECTS -- EFFECTS ON VOLUNTEERS -- REFERENCES -- CONCLUSIONS -- 3 PSYCHOCHEMICALS -- BACKGROUND -- REFERENCES -- VOLUNTEER SCREENING, SELECTION, AND CLASSIFICATION -- REVIEW OF AVAILABLE INFORMATION ON PHENCYCLIDINE -- CHEMISTRY -- ABSORPTION, FATE, AND ELIMINATION -- Absorption -- Distribution -- Metabolism -- Elimination (Pharmacokinetics) -- ANIMAL TOXICOLOGY -- NEUROPHARMACOLOGY -- GENETIC AND REPRODUCTIVE EFFECTS -- Mutagenicity -- Teratogenic-Reproductive Effects -- Summary -- DELAYED AND LONG-TERM EFFECTS -- Prolonged Psychotic Reactions -- Organic Brain Damage -- Residual Trauma in Connection with the Intoxicated State -- Food and Drug Administration Reports of Adverse Reactions -- Summary -- EFFECTS ON VOLUNTEERS -- REFERENCES.

REVIEW OF AVAILABLE INFORMATION ON DIBENZOPYRANS: DIMETHYLHEPTYLPYRAN AND RELATED COMPOUNDS -- CHEMISTRY -- ABSORPTION, FATE, AND ELIMINATION -- Absorption -- Distribution -- Metabolism -- Elimination -- ANIMAL TOXICOLOGY -- Route of Administration and Vehicle -- Toxicity of DMHP -- Toxicity of DMHP Acetate (EA 2233) -- MECHANISM OF ACTION -- NEUROPHARMACOLOGY -- MUTAGENICITY, TERATOGENICITY, AND CARCINOGENICITY -- DELAYED AND LONG-TERM EFFECTS -- EFFECTS ON VOLUNTEERS -- REFERENCES -- CONCLUSIONS -- 4 IRRITANTS AND VESICANTS -- BACKGROUND -- REFERENCES -- MUSTARD GAS -- CHARACTERISTICS -- TOXICOLOGY -- Mutagenicity -- Pathogenesis of Skin Lesions -- Carcinogenicity -- INDUSTRIAL AND MILITARY EXPOSURES -- MEDICAL EFFECTS -- Immediate Effects -- Injury to Skin -- Eye Injuries -- Injury to the Respiratory System -- Injury to the Nervous System and Other Organ Systems -- Systemic Effects -- Long-Term Morbidity -- WORLD WAR I CASUALTIES: SEQUELAE -- Tuberculosis -- Cancer -- EFFECTS ON HUMAN SUBJECTS AT EDGEWOOD -- SUMMARY -- REFERENCES -- O-CHLOROBENZYLIDENE MALONONITRILE -- CHARACTERISTICS -- BIOCHEMISTRY AND PHYSIOLOGY -- TOXICOLOGY IN IN VITRO AND ANIMAL STUDIES -- Mutagenicity -- Teratogenicity -- Carcinogenicity -- Lethal Effects -- Ocular Effects -- Cutaneous Effects -- Tests of CS-Loaded Pen Guns -- TOXICOLOGY IN HUMANS -- Immediate Effects -- Experimental Human Exposures -- Tolerance -- Sensitization -- Accidental Exposures -- USE IN NORTHERN IRELAND -- Himsworth Report, Part I -- Himsworth Report, Part II -- Mental Effects of Riots -- LONG-TERM FOLLOWUP -- EFFECTS ON HUMAN SUBJECTS AT EDGEWOOD -- SUMMARY -- REFERENCES -- CHLOROACETOPHENONE -- CHARACTERISTICS -- TOXICOLOGY IN IN VITRO AND ANIMAL STUDIES -- TOXICOLOGY IN HUMAN STUDIES -- Immediate Effects -- Injuries in Confined Spaces -- Wind-Tunnel Aerosol Tests in Man.

Effectiveness, Lethality, and Tolerance Time -- TEAR-GAS WEAPONS -- Forensic Aspects -- Experimental Studies -- Accidental Injuries -- SENSITIZATION IN HUMANS -- LONG-TERM EFFECTS -- EFFECTS ON HUMAN SUBJECTS AT EDGEWOOD -- DISCUSSION -- SUMMARY -- REFERENCES -- DIBENZ[B,F][1,4]OXAZEPINE -- CHARACTERISTICS -- CYTOTOXICITY -- TOXICITY IN ANIMALS -- Acute Effects -- Ocular Effects -- Lung Effects -- Metabolism and Physiology -- TOXICITY IN HUMANS -- Ocular Effects -- Cutaneous Effects -- Physiologic Studies -- EFFECTS ON HUMAN SUBJECTS AT EDGEWOOD -- SUMMARY -- REFERENCES -- DIPHENYLAMINOCHLORARSINE -- CHARACTERISTICS -- TOXICITY IN ANIMALS -- TOXICITY IN HUMANS -- EFFECTS ON HUMAN SUBJECTS AT EDGEWOOD -- SUMMARY -- REFERENCES -- BROMBENZYL CYANIDE -- CHARACTERISTICS -- TOXICITY IN ANIMALS -- TOXICITY IN HUMANS -- EFFECTS ON HUMAN SUBJECTS AT EDGEWOOD -- SUMMARY -- REFERENCES -- CHLOROPICRIN -- CHARACTERISTICS -- TOXICITY IN ANIMALS -- TOXICITY IN HUMANS -- MUTAGENICITY -- CARCINOGENICITY -- EFFECTS ON HUMAN SUBJECTS AT EDGEWOOD -- DISCUSSION -- SUMMARY -- REFERENCES -- NONANOYL MORPHOLIDE -- CHARACTERISTICS -- TOXICITY IN ANIMALS -- TOXICITY IN HUMANS -- EFFECTS ON HUMAN SUBJECTS AT EDGEWOOD -- DISCUSSION -- REFERENCES -- 1-METHOXY-1,3,5-CYCLOHEPTATRIENE -- CHARACTERISTICS -- TOXICITY IN ANIMALS -- TOXICITY IN HUMANS -- MUTAGENICITY -- EFFECTS ON HUMAN SUBJECTS AT EDGEWOOD -- SUMMARY -- REFERENCES -- EFFECTS OF HUMAN EXPOSURES TO 123 IRRITANT CHEMICALS AT EDGEWOOD IN TWO-MAN TESTS -- AGENTS THAT CAUSED SLIGHT OR NO EFFECTS -- LACRIMATORY AGENTS -- RESPIRATORY IRRITANTS -- CONCLUSIONS -- MUSTARD GAS (H) -- o-CHLOROBENZYLIDENE MALONONITRILE (CS) -- CHLOROACETOPHENONE (CN) -- DIBENZ[b,f][1,4]OXAZEPINE (CR) -- CHLOROPICRIN (PS) -- BROMBENZYL CYANIDE (CA), DIPHENYLAMINOCHLORARSINE (DM), and 1-METHOXY-1,3,5-CYCLOHEPTATRIENE (CHT) -- NONANOYL MORPHOLIDE.

123 IRRITANT CHEMICALS -- APPENDIX A Part 1. Reproduced from Volume I, Anticholinesterases and Anticholinergics -- HISTORY OF THE EDGEWOOD TESTING PROGRAM -- INTRODUCTION -- PROCEDURES USED AT THE EDGEWOOD CHEMICAL TESTING PROGRAM -- RECRUITMENT OF VOLUNTEERS -- GUIDELINES FOLLOWED IN THE PROTECTION OF SUBJECTS -- INVESTIGATORS -- SELECTION OF DOSES FOR HUMAN TESTS -- RANGE OF DOSES -- SAFETY MARGIN -- APPENDIX A Part 2. Clinical Research Department, SOP No. 5, August 12, 1968 (Revised) -- VOLUNTEER SCREENING AND SELECTION -- APPENDIX B DIGEST REPORT OXIMES -- INTRODUCTION -- LETHALITY OF SINGLE DOSES IN EXPERIMENTAL ANIMALS -- TOXICITY OF REPEATED DOSES IN EXPERIMENTAL ANIMALS -- SIDE EFECTS OF OXIMES IN MAN -- MODIFICATIONS OF NORMAL FUNCTIONS BY OXIMES -- METABOLISM OF OXIMES -- STUDIES WITH HUMAN SUBJECTS -- GENERAL COMMENT -- REFERENCES.