MEDICINAL CHEMISTRY RESEARCH PROGRESS -- Contents -- Preface -- An Open Letter to the Community of Organic Chemists -- References -- Alzheimer's Disease, the Importance of Aβ and the Hopes for Chemo Preventatives -- Abstract -- Introduction -- What Causes AD? -- Molecular Mechanisms and Risk Factors -- Hurdles in AD Research -- Approaches to Develop Safe and Effective Therapeutics -- Model Systems for Evaluation of AD Chemo Preventatives -- Therapeutic Perspectives -- Candidate Chemo Preventatives under Investigation -- Conclusion -- Web References for Updates on AD Research -- References -- Novel Class of Antibacterial Agents: Inhibitors of Enoyl-acyl Carrier Protein Reductases FabI and Fabk -- Abstract -- Introduction -- Discovery of FabI Inhibitor [49]-[52] -- Discovery of FabK Inhibitor [62]-[66], [52] -- Discovery of Dual Inhibitor of FabI/FabK [65], [67], [52] -- Conclusion -- Acknowledgements -- References -- Progress in the Discovery of SERCA Inhibitors -- Abstract -- SERCA Function and Structure -- SERCA Inhibition -- Bioassays for the Evaluation of SERCA Inhibitory Activity -- SERCA as a Target for Cancer Chemotherapy -- Hydroquinone-Based Inhibitors -- Cyclopiazonic Acid -- 1,3-Dibromo-2,4,6-tris(Methylisothiouronium) Benzene Tribromide -- Clotrimazole -- C-19 Terpenolides -- Naphthoquinones -- Curcumin -- Conclusion -- References -- G-Quadruplex Interactive Telomerase Inhibitors: An Exciting Field to Be Explored, with Some Open Challenges on the Biological Evaluation -- Abstract -- Introduction -- G-Quadruplex Interactive Compounds as Telomerase Inhibitors -- Study of the Interactions of the Ligands with Quadruplex and Duplex DNA -- Study of the Biological Activity (TRAP Assay) -- Conclusion -- References -- Polyethylenimine in Medicinal Chemistry -- Abstract -- Introduction -- References.

Multifunctional Delivery Vehicles for Biomedical Applications: Polyethylenimine as a Multipurpose Polymer -- Abstract -- Introduction -- Conclusion -- References -- Putative Bioactive Conformers of Small Molecules: A Concerted Approach Using NMR Spectroscopy and Computational Chemistry -- Abstract -- Introduction -- Conformational Analysis of AT1 Antagonists -- Conformational Analysis of Cannabinoids -- Conformational Analysis of Linear and Cyclic Peptides -- References -- The N-Terminal Part of the Ligand-Binding Domain of the Human Estrogen Receptor α: A New Target for Estrogen Disruptors -- Abstract -- Introduction -- The AF-2 Coactivator Binding Site -- Coregulator Binding Inhibitors -- A New Potential Target for CBIs -- The ER Inhibitory Function (IF) -- Modulation of "IF" Activity -- References -- Some Anticancer Targets with Peptidomimetics as Ligands -- Abstract -- 1. Introduction -- 2. Current Some Anticancer Targets with Peptidomimetic as Ligands -- 3. Current Peptidomimetics Anticancer Agents in Clinic or on Sale -- 4. Discussions and Perspectives -- References -- Index.