THE CHILDREN OF ATOMIC BOMB SURVIVORS -- Copyright -- Preface -- Contents -- Orientation -- BEGINNINGS -- THE THREE PHASES OF THE STUDY -- Phase I (1948-1954) -- Phase II (1955-1968) -- Phase III (1969-1990) -- AN ESTIMATE OF THE GENETIC DOUBLING DOSE OF RADIATION -- REFERENCES -- Genetic Effects of the Atomic Bombs in Hiroshima and Nagasaki -- THE EFFECT OF EXPOSURE TO THE ATOMIC BOMBS ON PREGNANCY TERMINATION IN HIROSHIMA AND NAGASAKI -- TABLE OF CONTENTS -- LIST OF TABLES -- LIST OF FIGURES -- CHAPTER I BACKGROUND -- CHAPTER II THE PLAN -- CHAPTER III A COMPARISON OF HIROSHIMA AND NAGASAKI -- CHAPTER IV THE CRITERIA OF RADIATION EMPLOYED IN THE STUDY -- CHAPTER V THE COMPARABILITY OF IRRADIATION SUBCLASSES -- CHAPTER VI STATISTICAL METHODS -- CHAPTER VII ANALYSIS OF THE SEX RATIO DATA -- CHAPTER VIII ANALYSIS OF THE MALFORMATION DATA -- CHAPTER IX ANALYSIS OF THE STILLBIRTH DATA -- CHAPTER X THE ANALYSIS OF THE BIRTHWEIGHT DATA -- CHAPTER XI ANALYSIS OF THE DATA CONCERNING DEATH DURING THE NINE-MONTH PERIOD FOLLOWING DELIVERY -- CHAPTER XII THE ANALYSIS OF THE ANTHROPOMETRIC DATA -- CHAPTER XIII THE AUTOPSY FINDINGS -- CHAPTER XIV RECAPITULATION -- CHAPTER XV PERMISSIBLE INFERENCES -- APPENDIX -- PROCEDURE FOR CODING GENETICS SHORT-FORM QUESTIONNAIRES -- CODING INSTRUCTIONS FOR GENETICS FOLLOW-UP QUESTIONNAIRES -- CODING INSTRUCTIONS FOR PEDIATRICS FOLLOW-UP QUESTIONNAIRE -- REFERENCES -- SUBJECT INDEX -- NAME INDEX -- ATOMIC BOMB EXPOSURE AND THE PREGNANCIES OF BIOLOGICALLY RELATED PARENTS A PROSPECTIVE STUDY OFGENETIC EFFECTS OF IONIZING… -- REFERENCES -- Some Further Observations on the Sex Ratio Among Infants Born to Survivors of the Atomic Bombings of Hiroshima and Nagasaki -- STUDIES OF THE SEX RATIO IN HIROSHIMA AND NAGASAKI -- DISCUSSION -- Other Studies of the Effect of Radiation on the Sex Ratio in Man.

On an Interpretation of the Present Studies -- SUMMARY -- REFERENCES -- A Cohort-Type Study of Survival in the Children of Parents Exposed to Atomic Bombings -- Factors Determining the Design of the Study -- DESCRIPTION OF STUDY PROCEDURES -- SOURCES OF VARIATION IN MORTALITY OTHER THAN RADIATION -- THE RELATIONSHIP OF MORTALITY TO EXPOSURE -- DISCUSSION -- EPILOGUE -- SUMMARY -- REFERENCES -- MORTALITY IN THE CHILDREN OF ATOMIC BOMB SURVIVORS AND CONTROLS -- ABSTRACT -- THE STUDY POPULATION -- STATISTICAL CONSIDERATIONS -- THE DATA -- DISCUSSION -- LITERATURE CITED -- 8 Cytogenetic Study of the Offspring of Atomic Bomb Survivors, Hiroshima and Nagasaki -- 1 INTRODUCTION -- 2 MATERIALS AND METHODS -- 3 RESULTS -- 3.1 Characteristics of the Study Sample -- 3.2 Types and Frequencies of Chromosome Abnormalities -- 3.2.1 Sex Chromosome Abnormalities -- 3.2.2 Autosomal Structural Rearrangements -- 3.2.3 Autosomal Trisomics -- 4 DISCUSSION -- REFERENCES -- Search for Mutations Altering Protein Charge and/or Function in Children of Atomic Bomb Survivors: Final Report -- SUMMARY -- INTRODUCTION -- THE PROTOCOL -- The Indicators -- The Study Cohorts -- Biochemical Procedures -- Special Studies of Putative Mutations -- Dosimetry -- RESULTS -- DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- Congenital Malformations, Stillbirths, and Early Mortality among the Children of Atomic Bomb Survivors: A Reanalysis -- INTRODUCTION -- MATERIALS AND METHODS -- The Study Sample -- Dosimetry -- Statistical Methods -- RESULTS -- UNCERTAINTIES -- Errors in the Estimation of the Gonadal Absorbed Doses -- Completeness of the Ascertainment of Death and Defect -- DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- Malignant Tumors during the First 2 Decades of Life in the Offspring of Atomic Bomb Survivors -- SUMMARY -- INTRODUCTION -- DESIGN OF STUDY.

Definition of Sample and Sources of Data -- Diagnostic Standards -- De Novo Origin of the Potentially Inherited Malignancies in the Study -- Dosimetry -- Statistical Procedures -- RESULTS OF ANALYSIS -- DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- Mortality among the Offspring (F1) of Atomic Bomb Survivors, 1946-85 -- SUMMARY -- INTRODUCTION -- DESIGN OF THE STUDY -- The population -- Dosimetry -- Characteristics of the study population -- Method of analysis -- RESULTS -- All causes of death and survival rates -- Excess relative risk for mortality -- DISCUSSION -- REFERENCES -- The Children of Parents Exposed to Atomic Bombs: Estimates of the Genetic Doubling Dose of Radiation for Humans -- SUMMARY -- INTRODUCTION -- BACKGROUND -- THE ESTIMATION OF THE AMOUNT OF RADIATION REACHING THE GONADS -- THE DATA -- 1. Untoward Pregnancy Outcomes -- 2. Deaths among Live-born Infants (exclusive of those resulting from a malignant tumor) -- 3. Malignancies in the F1 -- 4. Frequency of Balanced Structural Rearrangements of Chromosomes -- 5. Frequency of Sex-Chromosome Aneuploids -- 6. Frequency of Mutation Altering Protein Charge or Function -- 7. Sex Ratio among Children of Exposed Mothers -- 8. Growth and Development of the F1 -- IMPLICATIONS OF THE DATA -- Approach 1 -- Approach 2 -- Approach 3 -- CALCULATION OF THE DOUBLING DOSE -- DISCUSSION -- The Extrapolation to the Effects of Chronic Radiation -- The Discrepancy between This Estimate of a Genetic Doubling Dose and That Projected from Studies on Mice -- The Future of These Studies -- ACKNOWLEDGMENTS -- APPENDIX THE MUTATIONAL COMPONENT IN THE INDICATORS -- REFERENCES -- THE COMPARATIVE RADIATION GENETICS OF HUMANS AND MICE -- Contents -- INTRODUCTION -- A PRECIS OF THE HUMAN DATA ON THE GENETIC EFFECTS OF ACUTE RADIATION -- THE GENERATION OF AN ESTIMATE OF THE DOUBLING DOSE FROM THE HUMAN DATA.

SOME UNUSUAL FEATURES OF THE ESTIMATE OF THE HUMAN DOUBLING DOSE -- PRECIS OF THE MOUSE DATA ON THE GENETIC EFFECTS OF ACUTE RADIATION -- THE GENERATION OF A DOUBLING DOSE FROM THE MOUSE DATA -- SOME UNUSUAL FEATURES OF THE ESTIMATE OF THE MOUSE DOUBLING DOSE (FROM THE STANDPOINT OF EXTRAPOLATION TO HUMANS) -- CONCLUSIONS -- ACKNOWLEDGMENTS -- Literature Cited -- The Future of These Studies -- CURRENT RESEARCH PROJECTIONS -- THE LIMITATIONS OF THE NEW TECHNOLOGIES -- PARALLEL ANIMAL STUDIES -- STAYING THE COURSE -- REFERENCES -- Biographical Sketches -- Name Index -- Subject Index.